红外光谱分析技术评价MRI对胆囊结石成分预判的研究  

Evaluation of MRI in predicting the composition of gallstone by infrared spectroscopy

作　　者：翟彦昌 国强[1] 康永强 陈强[2] 刘帅[1] ZHAI Yanchang;GUO Qiang;KANG Yongqiang;CHEN Qiang;LIU Shuai(The Second Department of General surgery,The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,Inner Mongolia,China;Department of MRI,The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,Inner Mongolia,China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院普外二科,内蒙古包头014010 [2]内蒙古科技大学包头医学院第一附属医院影像科核磁共振室,内蒙古包头014010

出　　处：《西部医学》2022年第12期1856-1862,共7页Medical Journal of West China

基　　金：包头医学院临床医学+X多学科联合科研基金计划(BYJJ-DXK 2022037)。

摘　　要：目的利用傅里叶变换红外光谱(FT-IR)检测胆囊结石成分,评价MRI对胆囊结石成分预判的准确性。方法选取2020年12月~2021年8月我院100例预行胆囊切除的胆石病患者,另取同期50例无结石患者的MRI做阴性对照。术前行MRI检查,术后取胆囊结石进行FT-IR分析,分析FT-IR图及与MRI的相关性。配对样本计数资料组间比较使用McNemar检验,使用Kappa检验、ROC曲线下面积AUC、灵敏度、特异度和准确度等指标对MRI预判结石成分的准确性进行评估。结果MRI各序列信号表现与FT-IR对比:McNemar=4.00、P=0.135,Kappa=0.962、P<0.05,AUC(95%CI)为0.980(0.943~0.996),准确度为97.33%,灵敏度为96.00%,特异度为100.00%,约登指数为0.96;MRI各序列信号值与FT-IR对比:McNemar=0.20,P=0.655,Kappa=0.953、P<0.05,AUC(95%CI)为0.975(0.935~0.994),准确度为96.67%,灵敏度为95.00%,特异度为100.00%,约登指数为0.95。结论MRI可以较准确地预判胆囊结石成分,可为临床诊疗胆石病提供新思路,为胆石病的预防及流行病学研究提供理论基础。Objective To evaluate the accuracy of MRI in predicting the composition of gallstones by Fourier transform infrared spectroscopy(FT-IR).Methods 100 patients with cholelithiasis who underwent pre-cholecystectomy were screened,and MRI of 50 patients without stones were taken as negative control.Preoperative MRI was performed,and postoperative cholecystolithiasis was analyzed by FT-IR.The correlation between FT-IR and MRI was analyzed,and McNemar test was used for comparison between matched sample count data groups.Kappa test,area AUC under ROC curve,sensitivity,specificity and accuracy were used to evaluate the accuracy of MRI stone composition prediction.Results Comparison of signal performance of each sequence of MRI with FT-IR:McNemar=4.00,P=0.135>0.05,kappa=0.962>0.7,P<0.05,AUC(95%CI)was 0.980(0.943-0.996),greater than 0.7,accuracy was 97.33%,sensitivity was 96.00%,specificity was 100.00%,and yoden index was 0.96.Comparison of signal values of each sequence of MRI with FT-IR:McNemar=0.20,P=0.655>0.05,it can be considered that there is no difference in the detection rate between the two methods,kappa=0.953>0.7,P<0.05,AUC(95%CI)was 0.975(0.935-0.994),greater than 0.7,accuracy was 96.67%,sensitivity was 95.00%,specificity was 100.00%,and yoden index was 0.95.In conclusion,there is no difference and good consistency between the two methods.Conclusion MRI can accurately predict the composition of gallstones,provide a new idea for clinical diagnosis and treatment of cholelithiasis,and provide a theoretical basis for the prevention and epidemiological study of cholelithiasis.

关 键 词：胆结石 MRI 傅里叶变换红外光谱 成分预判 

分 类 号：R575.62[医药卫生—消化系统]