阿戈美拉汀与氟西汀治疗首发抑郁症疗效及其对认知功能影响的比较  

Comparative study on the efficacy and cognitive function of agomelatine and fluoxetine in the treatment of first episode depression

作　　者：李彩霞[1] LI Caixia(Department of Pharmacy,the First Affiliated Hospital of Xiamen University,Xiamen 361001,China)

机构地区：[1]厦门大学附属第一医院药剂科,福建省厦门市361001

出　　处：《临床合理用药杂志》2022年第33期21-25,共5页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的比较阿戈美拉汀与氟西汀治疗首发抑郁症的疗效及其对认知功能的影响。方法选取70例确诊为首发抑郁症患者为研究对象,均为厦门大学附属第一医院2021年2月—2022年2月收治的患者,根据随机数字表法予以分组,分为氟西汀组35例与阿戈美拉汀组35例。氟西汀组患者予以氟西汀胶囊,阿戈美拉汀组患者予以阿戈美拉汀片,2组均连续用药8周。比较2组治疗效果,治疗前及连续用药8周后匹兹堡睡眠质量指数量表(PSQI)评分、韦氏成人智力量表评分、韦氏成人记忆量表评分、汉密尔顿抑郁量表(HAMD)评分及生活质量评分,并统计分析2组不良反应。结果阿戈美拉汀组总有效率为97.14%(34/35),高于氟西汀组的80.00%(28/35)(χ^(2)=5.081,P=0.024)。连续用药8周后,2组入睡时间、睡眠质量及睡眠障碍评分较治疗前降低,且阿戈美拉汀组较氟西汀组更低(P<0.05);连续用药8周后,2组韦氏成人智力量表评分、韦氏成人记忆量表评分较同组治疗前分别升高,且阿戈美拉汀组较氟西汀组更高(P<0.01);2组HAMD评分较治疗前降低,且阿戈美拉汀组较氟西汀组更低(P<0.01);相较于氟西汀组,阿戈美拉汀组生活质量各因子评分更高(P<0.01)。阿戈美拉汀组不良反应总发生率为2.86%(1/35),与氟西汀组的8.57%(3/35)比较,差异无统计学意义(χ^(2)=0.265,P=0.607)。结论与氟西汀比较,阿戈美拉汀治疗首发抑郁症的疗效更佳,可更有效地改善患者认知功能,纠正不良的睡眠状态,减轻抑郁症状,且用药后不良反应较少。Objective To compare the efficacy and cognitive function of agomelatine and fluoxetine in the treatment of first episode depression.Methods A total of 70 cases of patients with first episode depression were selected from February 2021 to February 2022 in the First Affiliated Hospital of Xiamen University,which were divided into fluoxetine group(35 cases)and agomelatine group(35 cases)according to the random number table method.Patients in fluoxetine group were given fluoxetine capsules,and patients in agomelatine group were given agomelatine tablets.Both groups were treated continuously for 8 weeks.Treatment effect,PSQI score,Wechsler Adult Intelligence Scale score,Wechsler Adult Memory Scale score,HAMD score and quality of life score before and after 8 weeks of continuous medication treatment were compared between the two groups.The adverse reactions of the two groups were statistically analyzed.Results The total effective rate of amerasidine group was 97.14%(34/35),which was higher than 80.00%(28/35)of fluoxetine group(χ^(2)=5.081,P=0.024).After 8 weeks of continuous treatment,the sleep time,sleep quality and sleep disorder scores of the two groups were lower than those of the same group before treatment,and those of the agomelatine group were lower than fluoxetine group(P<0.05).After 8 weeks of continuous treatment,the scores of Wechsler Adult Intelligence Scale and Wechsler Adult Memory Scale of the two groups were higher than those of the same group before treatment,and the scores of agomelatine group were higher than those of fluoxetine group(P<0.01).After 8 weeks of continuous treatment,HAMD score of the two groups was lower than that of the same group before treatment,and that of agomelatine group was lower than fluoxetine group(P<0.01).After 8 weeks of continuous treatment,the scores of quality of life factors in agomelatine group were higher than those in fluoxetine group(P<0.01).The total incidence of adverse reactions in the agomelatine group was 2.86%(1/35),which was not significantly different from

关 键 词：首发抑郁症 阿戈美拉汀 氟西汀 认知功能 疗效比较研究 不良反应 

分 类 号：R749.4[医药卫生—神经病学与精神病学]