内镜下放射状切开联合曲安奈德局部注射治疗早期食管癌内镜黏膜下剥离术后难治性食管狭窄的疗效分析  

The effective analysis of refractory esophageal stricture after endoscopic mucosal dissection of early esophageal cancer treated by endoscopic radiotomy combined with local injection of triamcinolone acetonide

作　　者：姚成云 伍海锐 刘勇 王贵齐 Yao Chengyun;Wu Hairui;Liu Yong;Wang Guiqi(Department of Endoscopy,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;National Cancer Center/National Clinical Research Center for Cancer,Beijing 100021,China)

机构地区：[1]中国医学科学院北京协和医学院肿瘤医院内镜科,北京100021 [2]国家癌症中心国家肿瘤临床医学研究中心,北京100021

出　　处：《中华医学杂志》2022年第39期3143-3146,共4页National Medical Journal of China

基　　金：中国医学科学院医学与健康科技创新工程(2021-I2M-1-061,2021-I2M-1-010)。

摘　　要：早期食管癌内镜切除术后难治性食管狭窄是临床上的难题。本研究为验证内镜下放射状切开联合曲安奈德局部注射治疗难治性食管狭窄的效果,回顾性分析了7例早期食管癌内镜黏膜下剥离术后发生难治性食管狭窄的患者资料,男4例,女3例,年龄50~76岁,平均63岁。对患者在内镜下选择瘢痕狭窄处最厚的部位行放射状切开及局部注射曲安奈德,结果提示内镜下放射状切开联合曲安奈德局部注射治疗早期食管癌内镜下黏膜剥离术后难治性食管狭窄安全、有效,随访结果提示未再发生食管狭窄,无出血、穿孔、肿瘤复发及曲安奈德过敏等不良反应。Refractor esophageal stenosis after endoscopic submucosal dissection of early esophageal carcinoma is a difficult clinical problem.To verify the effect of endoscopic radial incision combined local triamcinolone injection to treat refractory esophageal stenosis,we retrospectively analyzed 7 patients diagnosed with refractory esophageal stricture after endoscopic mucosal dissection of early esophageal cancer in this study,of whom 4 male and 3 female patients,aged 50-76 years,with the mean age of 63 years.We performed the endoscopic radial incision in the thickness point of the scar stricture and injected the triamcinolone locally.The results showed it was safe and effective.The follow-up showed no esophageal stenosis occured and no adverse reaction such as hemorrhage,perforation,tumor-recurrence and triamcinolone-allergy occured.

关 键 词：食管癌 早期 难治性食管狭窄 内镜下放射状切开 曲安奈德 局部注射 内镜下治疗 横断面研究 

分 类 号：R735.1[医药卫生—肿瘤]