实时动态超声造影在多囊肝射频消融术治疗中的有效性及安全性分析  

Efficacy and safety of real-time dynamic contrast-enhanced ultrasound in the treatment of polycystic liver radiofrequency ablation

作　　者：方崟又 陈志丞 宗方[1] FANG Yinyou;CHEN Zhicheng;ZONG Fang(Department of Ultrasound,Yiwu Central Hospital,Zhejiang,Yiwu 322000,China)

机构地区：[1]义乌市中心医院超声科,浙江义乌322000

出　　处：《中国现代医生》2022年第34期54-57,共4页China Modern Doctor

摘　　要：目的探讨实时动态超声造影在多囊肝射频消融术(radiofrequency ablation,RFA)治疗中的有效性及安全性。方法选取2018年5月至2019年6月于义乌市中心医院行RFA的98例多囊肝患者为研究对象,根据随机数字表法将其分为造影组(n=49)和常规组(n=49)。术前两组患者均行CT及磁共振成像检查,常规组患者常规超声引导行RFA,造影组患者行实时动态超声造影检查后超声引导下行RFA。比较两组患者的肝功能、肝内囊肿总体积、术后肝囊肿总体积缩小率、完全灭活数、局部残存数及不良反应发生情况。结果术后6个月,两组患者的肝囊肿体积均显著缩小,造影组患者的肝囊肿体积显著小于常规组(P<0.05),术后肝囊肿总体积缩小率显著大于常规组(P<0.05),术后完全灭活率显著高于常规组(P<0.05);术前和术后1周,两组患者的丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素比较差异均无统计学意义(P>0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论实时动态超声造影可有效提高多囊肝RFA的治疗效果,减少术后局部残留数,且未加重肝脏负荷,适宜临床推广。Objective To investigate the efficacy and safety of real-time dynamic contrast-enhanced ultrasound in the treatment of polycystic liver radiofrequency ablation(RFA).Methods A total of 98 patients with polycystic liver who underwent RFA in Yiwu Central Hospital from May 2018 to June 2019 were selected as the research objects.According to the random number table method,they were divided into angiography group(n=49)and conventional group(n=49).Preoperative CT and magnetic resonance imaging were performed in both groups.Patients in conventional group underwent conventional ultrasound guided RFA and patients in angiography group underwent contrasted-ultrasound examination followed by ultrasound-guided RFA.The liver function,the total volume of intrahepatic cysts,the reduction rate of total volume of intrahepatic cysts,the number of complete inactivation,the number of local residual and the incidence of adverse reactions were compared between the two groups.Results At 6 months after surgery,the volume of liver cysts in two groups was significantly reduced.The volume of liver cysts in angiography group was significantly smaller than that in conventional group(P<0.05),the reduction rate of total volume of intrahepatic cysts after surgery was significantly higher than that in conventional group(P<0.05),and the complete inactivation rate after surgery was significantly higher than that in conventional group(P<0.05).There was no significant difference in alanine aminotransferase,aspartate aminotransferase and total bilirubin between the two groups before surgery and 1 week after surgery(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Real-time dynamic contrast-enhanced ultrasound can effectively improve the treatment effect of polycystic liver RFA,reduce the number of postoperative local residual and no aggravation of liver burden,which is suitable for clinical promotion.

关 键 词：实时动态超声造影 多囊肝 射频消融术 有效性 安全性 

分 类 号：R445.1[医药卫生—影像医学与核医学]