全身麻醉复合硬膜外阻滞对卵巢癌围手术期镇痛和血流动力学及免疫功能的影响  

Effects of general anesthesia combined with epidural block on perioperative analgesia,hemodynamics and immune function in patients with ovarian cancer

作　　者：薛行行 薛蓉 XUE Hang-hang;XUE Rong(Department of Anesthesiology,The First Hospital of Yulin,Yulin 718000,China)

机构地区：[1]陕西省榆林市第一医院麻醉科,榆林718000

出　　处：《中国肿瘤临床与康复》2022年第12期1437-1441,共5页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨全身麻醉复合硬膜外阻滞对卵巢癌围手术期镇痛、血流动力学及免疫功能的影响。方法选取2019年5月至2021年2月间榆林市第一医院收治的106例卵巢癌患者为研究对象,采用随机数表法将其分为复合组与对照组,每组53例。两组患者均行卵巢癌根治术治疗,对照组给予全身麻醉,复合组给予全身麻醉联合硬膜外阻滞。对比两组手术相关指标(术中出血量、手术时间以及住院时间),比较术前(T)、麻醉后30min(T)、术毕(T)、术后2 h(T)两组视觉模拟评分(VAS)、平均动脉压(MAP)、心率(HR)、CD3^(+)、CD4^(+)水平,记录两组术后3 d内不良反应发生情况。结果两组术中出血量、手术时间比较,差异无统计学意义(P>0.05)。复合组住院时间短于对照组,差异有统计学意义(P<0.05)。两组T时刻VAS评分比较,差异无统计学意义(P>0.05)。两组T时刻VAS评分低于T、T、T时刻;两组T时刻VAS评分低于T、T时刻;两组T时刻VAS评分低于T时刻;且复合组T、T、T时刻VAS评分低于对照组,差异均有统计学意义(均P<0.05)。两组T时刻MAP、HR比较,差异无统计学意义(P>0.05)。两组T时刻MAP高于T时刻,低于T、T时刻;两组T时刻MAP高于T、T时刻;两组T时刻MAP高于T时刻,差异均有统计学意义(均P<0.05)。两组T时刻HR高于T、T、T时刻;两组T时刻HR高于T时刻,低于T时刻;两组T时刻HR低于T时刻;且复合组T、T、T时刻MAP、HR低于对照组,差异均有统计学意义(均P<0.05)。两组T时刻CD3^(+)、CD4^(+)比较,差异无统计学意义(P>0.05)。两组T时刻CD3^(+)、CD4^(+)低于T、T、T时刻;两组T时刻CD3^(+)、CD4^(+)低于T、T时刻;两组T时刻CD3^(+)、CD4^(+)低于T时刻;且复合组T、T、T时刻CD3^(+)、CD4^(+)高于对照组,差异均有统计学意义(均P<0.05)。两组术后3 d内总不良反应发生率比较,差异无统计学意义(P>0.05)。结论全身麻醉复合硬膜外阻滞用于卵巢癌根治术,可缩短住院时间,减轻�Objective To investigate the effects of general anesthesia combined with epidural block on perioperative analgesia,hemodynamics and immune function in patients with ovarian cancer.Methods A total of 106 patients with ovarian cancer admitted to The First Hospital of Yulin from May 2019 to February 2021 were selected.They were divided into a composite group and a control group with 53 patients in each group using the random table method.Both groups underwent radical resection for ovarian cancer.The control group was given general anesthesia,and the composite group was given general anesthesia combined with epidural anesthesia.Surgery-related indicators including intraoperative blood loss,duration of operation and length of hospital stay were compared between the two groups.Visual analogue scale(VAS),mean arterial pressure(MAP),heart rate(HR),and CD3^(+)and CD4^(+)levels are compared between the two groups before operation(T),at 30 min after anesthesia(T),at the end of operation(T),and at 2 hours after the operation(T).The occurrence of adverse reactions in the two groups within 3 days after operation was recorded.Results There was no significant difference in intraoperative blood loss and operation time between the two groups(P>0.05).Length of hospital stay was shorter in the composite group than in the control group(P<0.05).There was no significant difference in VAS scores between the two groups at T(P>0.05).The VAS scores were lower at Tthan T,Tand T,were lower at Tthan Tand T,and were lower at Tthan at Tin the two groups(all P<0.05).The VAS score was lower in the composite group than in the control group at T,T,and T(all P<0.05).There was no statistically significant difference in MAP and HR between the two groups at T(P>0.05).MAP in the two groups was higher at Tthan at Tand lower than at Tand T(all P<0.05).MAP in the two groups was higher at Tthan at Tand T(P<0.05).MAP in the two groups at time Twas higher than at T(all P<0.05).HR in the two groups was higher at time Tthan at time T,Tand T(all P<0.05),and HR i

关 键 词：全身麻醉 硬膜外阻滞 卵巢肿瘤 围手术期 镇痛 血流动力学 免疫功能 

分 类 号：R737.31[医药卫生—肿瘤]