CT引导下多极射频消融和全雄激素阻断治疗前列腺癌的效果观察  

Efficacy of CT-guided multipolar radiofrequency ablation and complete androgen deprivation in the treatment of prostate cancer

作　　者：袁海军 张向梅 李亚宝 YUAN Hai-jun;ZHANG Xiang-mei;LI Ya-bao(Imaging Center,Jingbian People's Hospital,Yulin 718500,China)

机构地区：[1]陕西省靖边县人民医院影像中心,榆林718500

出　　处：《中国肿瘤临床与康复》2022年第11期1301-1304,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨CT引导下多极射频消融配合全雄激素阻断治疗前列腺癌的效果及对血前梯度蛋白2(AGR2)、中性粒细胞计数与淋巴细胞计数的比值(NLR)表达的影响。方法选取2018年1月至2021年1月间靖边县人民医院收治的78例前列腺癌患者作为研究对象,采用随机数表法分为观察组和对照组,每组39例,对照组接受全雄激素阻断治疗,观察组在对照组基础上,利用CT做引导,进行多极射频消融治疗。对比近期疗效、国际前列腺症状评分(IPSS)、生活质量评分(QOL)、最大尿流率(Qmax)、前列腺特异性抗原(PSA)水平、血AGR2及NLR表达水平。结果观察组疾病控制率为87.2%,对照组为71.8%,观察组高于对照组,差异有统计学意义(P<0.05)。干预前,两组患者PISS评分、QOL评分、Qmax及PSA水平比较,差异无统计学意义(P>0.05)。干预后,观察组PISS评分、QOL评分及PSA均低于对照组,Qmax高于对照组,差异均有统计学意义(均P<0.05)。干预前,两组患者血AGR2、NLR水平比较,差异无统计学意义(P>0.05)。干预后,观察组血AGR2、NLR水平均低于对照组,差异均有统计学意义(均P<0.05)。结论CT引导下多极射频消融配合全雄激素阻断治疗前列腺癌患者能够取得良好的效果,改善患者AGR2、NLR的表达水平,提升患者生活质量。Objective To investigate the efficacy of CT-guided multipolar radiofrequency ablation combined with complete androgen deprivation in the treatment of prostate cancer and its effect on the expression of anterior gradient protein 2 homolog(AGR2)and the neutrophil-to-lymphocyte ratio(NLR).Methods A total of 78 patients with prostate cancer who were treated at Jingbian People's Hospital were selected from January 2018 to January 2021.They were randomly divided into an observation group and a control group with 39 patients in each group.The control group was given complete androgen deprivation therapy and the observation group was given multipolar radiofrequency ablation using CT as guidance in addition to complete androgen deprivation.Short-term efficacy,international prostate symptom score(IPSS),quality of life(QOL),the maximum flow rate(Qmax),prostate-specific antigen(PSA)level,serum expression of AGR2 and NLR level were compared between the two groups.Results The disease control rate was 87.2% in the in the observation group,which was higher than 71.8% of the control group(P<0.05).There was no statistically significant difference in PISS score,QOL score,Qmax and PSA levels between the two groups before the intervention(P>0.05).After intervention,PISS score,QOL score and PSA levels were lower in the observation group than in the control group and Qmax was higher in the observation group than in the control group(all P<0.05).There was no significant difference in ACR2 and NLR between the two groups before intervention(P>0.05).AGR2 and NLR were lower in the observation group than in the control group after the intervention(all P<0.05).ConclusionCT-guided multipolar radiofrequency ablation combined with complete androgen deprivation in the treatment of prostate cancer patients can achieve good outcomes,which improves the expression levels of AGR2 and NLR and quality of life.

关 键 词：多极射频消融 全雄激素阻断治疗 前列腺肿瘤 临床效果 

分 类 号：R737.25[医药卫生—肿瘤]