机械应力在髁突发育中的作用  

Regulatory Role of Mechanical Stress in Condylar Development

作　　者：杨学文 刘瞻 YANG Xuewen;LIU Zhan(Department of Orthognathic&Cleft Lip and Palate Plastic Surgery,Hospital of Stomatology,Wuhan University,Wuhan 430079,China)

机构地区：[1]武汉大学口腔医院正颌与唇腭裂整形外科,湖北武汉430079

出　　处：《口腔医学研究》2022年第12期1105-1109,共5页Journal of Oral Science Research

摘　　要：髁突既是下颌骨的生长发育中心,也是颞下颌关节的重要组成部分,在咀嚼、语言等生理活动中发挥重要作用。髁突发育异常所导致的下颌骨畸形有多种表现形式,颌骨畸形不仅影响患者的容貌和咬合关系,也给年轻患者造成一定心理创伤。引起髁突发育异常的病因一直是人们关注的重点,随着研究的深入,越来越多的证据表明,异常的机械应力是影响颌骨发育及导致颌骨畸形的重要原因,这种观点也逐渐引起人们的重视。本文将以偏颌畸形为例,总结机械应力对髁突生长发育的影响,并且分析与机械应力调控髁突发育有关的多种机械敏感性离子通道及信号通路,为深入研究髁突发育异常导致的颌骨畸形的相关机制及早期治疗提供新思路。The condyle,a growth and development center of the mandible and an important component of the temporomandibular joint,plays a crucial role in physiological activities such as mastication and speech.There are many mandibular deformities caused by abnormal condylar development.These jaw deformities not only affect the appearance and occlusal relationship,but also cause some psychological trauma to young patients.The etiology of abnormal condylar development has drawn significant interest.More and more evidences indicate that abnormal mechanical stress is an important reason of jaw deformity.In this paper,we will summarize the effects of mechanical stress in condylar growth and development,discuss the regulatory role of mechanosensitive ion channels and signaling pathways in condylar development.This review is expected to contribute several ideas for the treatment of dental and maxillofacial malformations.

关 键 词：机械应力 髁突发育 偏颌畸形 离子通道 信号通路 

分 类 号：R782.2[医药卫生—口腔医学]