CDK蛋白在HIV-1复制中的作用研究进展  

Research Progress on the Role of CDK Proteins in HIV-1 Replication

作　　者：王淑杰 陈淑敏[2] 丁寄葳[1] 岑山[1] 李晓宇[1] WANG Shujie;CHEN Shumin;DING Jiwei;CEN Shan;LI Xiaoyu(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China;The Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]中国医学科学院,北京协和医学院,医药生物技术研究所,北京100050 [2]青岛大学附属医院,青岛266000

出　　处：《病毒学报》2022年第6期1503-1511,共9页Chinese Journal of Virology

基　　金：国家自然科学基金委面上项目(项目号:81772205),题目:HIV-1宿主限制因子SAMHD1的dNTPase非依赖抗病毒机制的研究;国家级大学生创新创业训练计划项目(项目号:201610443014),题目:抗老年痴呆药物脂质体的制备及缓释性能的研究。

摘　　要：人类免疫缺陷综合征(Acquired immunodeficiency syndrome,AIDS)是由人免疫缺陷病毒(Human immunodeficiency virus,HIV)感染引起的慢性传染性疾病。HIV根据病毒基因组结构的差异分为HIV-1和HIV-2,而HIV-1是主要的病原体。细胞周期蛋白依赖性激酶(Cyclin dependent kinases,CDKs)在HIV-1复制过程中不可或缺,尤其是在逆转录、转录及病毒RNA加工过程中起到至关重要的作用。本文对CDKs结构、分类及其在HIV-1复制中发挥的作用展开综述,以期为开发针对CDKs靶点的抗HIV-1药物和艾滋病治疗提供线索与思路。Acquired Immunodeficiency Syndrome(AIDS)is a chronic infectious disease caused by human immunodeficiency virus(HIV)infection.HIV is classified into HIV-1 and HIV-2 according to differences in the structure of the viral genome,and HIV-1 is the main pathogen.Cyclin-dependent kinases(CDKs)are indispensable for viral replication,especially for reverse transcription,transcription,and RNA processing of HIV-1.We review the structure and classification of CDKs and their role in HIV-1 replication.We hope to provide clues and ideas for the development of anti-HIV-1 drugs and AIDS treatments targeting CDKs.

关 键 词：HIV-1 CDKS 转录 逆转录 RNA加工 

分 类 号：R373.9[医药卫生—病原生物学]