深海来源篮状菌Talaromyces indigoticus FS688中聚酮化合物及其细胞毒性  

Polyketides from the Deep-Sea-Derived Fungus Talaromyces indigoticus FS688 and Their Cytotoxicites

作　　者：李明琼 黄惠彬 陈玉婵 李赛妮 刘昭明 王彦林[3] 章卫民 高晓霞 Mingqiong Li;Huibin Huang;Yuchan Chen;Saini Li;Zhaoming Liu;Yanlin Wang;Weimin Zhang;Xiaoxia Gao(School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006;Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,State Key Laboratory of Applied Microbiology Southern China,Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou 510070;Key Laboratory of Ocean and Marginal Sea Geology,Innovation Academy of South China Sea Ecology and Environmental Engineering,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301)

机构地区：[1]广东药科大学药学院,广州510006 [2]广东省科学院微生物研究所华南应用微生物国家重点实验室广东省菌种保藏与应用重点实验室,广州510070 [3]中国科学院南海海洋研究所南海生态环境工程创新研究院边缘海与大洋地质重点实验室,广州510301

出　　处：《有机化学》2022年第9期2975-2980,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.41906106,31272087);广东省海洋经济发展专项基金(No.GDNRC[2021]054);国家自然科学基金委员会共享航次计划(Nos.41849906,41949906)资助项目;该航次(航次编号:NORC2019-06,NORC2020-06)由“嘉庚”号科考船实施.

摘　　要：对深海来源真菌Talaromyces indigoticus FS688进行化学成分研究,从中发现了3个新的聚酮类化合物以及5个已知化合物,其化学结构是通过综合的波谱分析得以确定,同时其绝对构型是通过理论电子圆二色谱(ECD)计算确定.其中,5-甲基六氢呋喃[2,3-b]呋喃-2-基-乙烷-1-醇(2)对所测试的4株人体肿瘤细胞株(SF-268,MCF-7,Hep G-2和A549)表现出显著的细胞毒活性, IC_(50)介于0.18~0.53μmol/L之间.The chemical investigation of the deep-sea-derived fungus Talaromyces indigoticus FS688 led to the isolation of three new polyketides together with five known compounds. Their structures were determined by comprehensive spectroscopic analysis and the absolute configurations were evaluated by theoretical electrostatic circular chroism(ECD) calculations.Among them, 5-methylhexahydrofuro[2,3-b]furan-2-yl-ethan-1-ol(2) exhibited significant cytotoxicity against the four tested human tumor cell lines(SF-268, MCF-7, HepG-2 and A549) with the IC_(50) values in the range of 0.18~0.53 μmol/L.

关 键 词：TALAROMYCES 深海真菌 聚酮 波谱分析 细胞毒 

分 类 号：TQ460.1[化学工程—制药化工]