醇与胺的不对称脱氢偶联升级反应研究进展  

Recent Progress in Upgrading of Alcohol and Amine via Asymmetric Dehydrogenative Coupling

作　　者：蒋滨阳 施世良 Jiang Binyang;Shi Shi-Liang(State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032)

机构地区：[1]中国科学院上海有机化学研究所,金属有机化学国家重点实验室,上海200032

出　　处：《有机化学》2022年第10期3263-3279,共17页Chinese Journal of Organic Chemistry

基　　金：国家重点研发计划(No.2021YFF0701600);国家自然科学基金(Nos.21871288,21821002,22171280);上海市科委(No.22XD1424900)资助项目。

摘　　要：手性醇及手性胺结构广泛存在于天然产物及药物分子中,因而发展其不对称合成具有重要研究意义.相较于传统方法,过渡金属催化的醇与胺的不对称脱氢偶联制备高级手性醇和胺的反应具有优秀的步骤经济性、原子经济性及氧化还原经济性,因而近年来得到了广泛的研究.这类反应可从简单原料出发一步合成结构多样的手性醇与手性胺类化合物.根据偶联试剂的种类进行划分,总结了醇、胺参与的各类不对称脱氢偶联升级反应,并对该领域的发展进行展望.Chiral alcohol and amine are ubiquitous in natural products and pharmaceutically relevant molecules. Thus,developing the asymmetric synthesis of these molecules is of great importance. Compared with traditional methods,transition-metal-catalyzed asymmetric dehydrogenative coupling of alcohol and amine to advanced chiral alcohol and amine has been widely studied due to its excellent step-, atom-and redox-economy. This method allows for the one-step synthesis of structurally diverse chiral alcohol and chiral amine compounds from simple starting materials. Various types of asymmetric dehydrogenative coupling upgrading reactions involving alcohols and amines according to the types of coupling reagents are summarized and the outlook on the development of the field is provided.

关 键 词：手性醇 手性胺 不对称金属催化 氢转移 脱氢偶联 碳碳成键反应 

分 类 号：O621.251[理学—有机化学]