Feature-based Quality Assessment of Middle Cerebral Artery Occlusion Using 18F-Fluorodeoxyglucose Positron Emission Tomography  

作　　者：Wuxian He Hongtu Tang Jia Li Chenze Hou Xiaoyan Shen Chenrui Li Huafeng Liu Weichuan Yu 

机构地区：[1]Department of Electronic and Computer Engineering,The Hong Kong University of Science and Technology,Hong Kong,China [2]Department of Acupuncture and Moxibustion,Hubei University of Chinese Medicine,Wuhan,430065,China [3]HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute,Futian,Shenzhen,China [4]College of Science,Zhejiang University of Technology,Hangzhou,310023,China [5]State Key Laboratory of Modern Optical Instrumentation,College of Optical Science and Engineering,Zhejiang University,Hangzhou,310027,China [6]Intelligent Optics&Photonics Research Center,Jiaxing Research Institute of Zhejiang University,Jiaxing,314000,China

出　　处：《Neuroscience Bulletin》2022年第9期1057-1068,共12页神经科学通报（英文版）

基　　金：supported by R4012-18,C6021-19EF and GRF 16306919 from the Research Grant Council(RGC);ITS/480/18FP and MHP/033/20;from the Innovation and Technology Commission(ITC)of the Hong Kong S.A.R.,Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone Projec(HZQB-KCZYB-2020083);the National Natural Science Foundation of China(U1809204);the Talent Program of Zhejiang Province(2021R51004)。

摘　　要：In animal experiments,ischemic stroke is usually induced through middle cerebral artery occlusion(MCAO),and quality assessment of this procedure is crucial.However,an accurate assessment method based on 18F-fluorodeoxyglucose(FDG)positron emission tomography(PET)is still lacking.The difficulty lies in the inconsistent preprocessing pipeline,biased intensity normalization,or unclear spatiotemporal uptake of FDG.Here,we propose an image feature-based protocol to assess the quality of the procedure using a 3D scale-invariant feature transform and support vector machine.This feature-based protocol provides a convenient,accurate,and reliable tool to assess the quality of the MCAO procedure in FDG PET studies.Compared with existing approaches,the proposed protocol is fully quantitative,objective,automatic,and bypasses the intensity normalization step.An online interface was constructed to check images and obtain assessment results.

关 键 词：Ischemic stroke Middle cerebral artery occlusion Brain metabolism FDG PET imaging SIFT classification 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R817.4[医药卫生—临床医学]