载药微球栓塞与传统化疗栓塞治疗不可切除肝细胞癌的临床研究  

Clinical study on the treatment of unresectable hepatocellular carcinoma by drug-loaded microsphere embolization and conventional chemotherapy embolization

作　　者：庞华春 傅健 曾令洋 PANG Huachun;FU Jian;ZENG Lingyang(Xinxing County People’s Hospital,Xinxing 527400,China)

机构地区：[1]新兴县人民医院,广东新兴527400

出　　处：《现代医院》2022年第12期1966-1968,共3页Modern Hospitals

基　　金：云浮市科技计划项目(200601105440275)。

摘　　要：目的探讨载药微球栓塞与传统化疗栓塞治疗不可切除肝细胞癌的临床研究。方法选择2020年7月—2021年12月期间收治的60例肝细胞癌患者,根据随机数字表法分为2组,传统组30例选择传统经肝动脉化疗栓塞术,载药组30例选择载药微球经肝动脉化疗栓塞术,观察两组患者治疗效果、肝功能指标及不良反应的发生。结果治疗后,载药组总有效率为93.33%(28/30)高于传统组70.00%(21/30),差异有统计学意义(P<0.05);两组ALT、AST较治疗前上升,且载药组ALT高于传统组,AST低于传统组;两组ALB均较治疗前下降,载药组低于传统组(P<0.05);载药组并发症发生率(6.66%)低于传统组(16.67%),但差异无统计学意义(P>0.05)。结论载药微球经肝动脉化疗栓塞术能够改善不可切除肝癌患者治疗的近期疗效,调节肝功能,且不增加不良反应的发生。Objective To explore the clinical study of drug-loaded microsphere embolization and traditional chemoembolization in the treatment of unresectable hepatocellular carcinoma.Methods To our hospital in 2020 July to December 2021,admitted during the period of 60 patients with hepatocellular carcinoma(HCC)as the research object,is divided into two groups according to random number table method,traditional group of 30 cases of selection into the hepatic artery chemoembolization,drug group of 30 cases choice carrier drug microsphere via hepatic artery chemoembolization,observation of therapeutic effect in both groups,liver function index and the occurrence of adverse reactions.Results After treatment,the total effective rate of the drug-loaded group was 93.33%(28/30),which was higher than 70.00%(21/30)of the traditional group,and the difference was statistically significant(P<0.05).ALT and AST in the two groups were higher than those before treatment,and ALT in the vehicle group was higher than that in the traditional group,and AST was lower than that in the traditional group.The ALB levels in the two groups were lower than those before treatment,and that in the vehicle group was lower than that in the traditional group(P<0.05).The incidence of complications in the drug-loaded group(6.66%)was lower than that in the traditional group(16.67%),but the difference was not statistically significant(P>0.05).Conclusion Transarterial chemoembolization with drug-loaded microspheres can improve the short-term efficacy of unresectable hepatocellular carcinoma and regulate liver function without increasing the incidence of adverse reactions.

关 键 词：载药微球栓塞 传统化疗栓塞 肝细胞癌 肝功能 

分 类 号：R735.7[医药卫生—肿瘤]