手性医药化学品的绿色生物合成  

Green biosynthesis of chiral pharmaceutical chemicals

作　　者：陈曦[1,2] 吴凤礼 樊飞宇 吴洽庆 朱敦明[1,2] CHEN Xi;WU Fengli;FAN Feiyu;WU Qiaqing;ZHU Dunming(Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China;National Technology Innovation Center of Synthetic Biology,Tianjin 300308,China)

机构地区：[1]中国科学院天津工业生物技术研究所,天津300308 [2]国家合成生物技术创新中心,天津300308

出　　处：《生物工程学报》2022年第11期4240-4262,共23页Chinese Journal of Biotechnology

基　　金：国家重点研发计划(2021YFC2102000)。

摘　　要：手性在自然界中普遍存在,与生命现象密切相关,也显著影响物质的性能。手性医药化学品的化学合成存在原子经济性、过程经济性差、环境污染和资源浪费严重等问题。生物合成技术具有过程绿色、选择性好等优势。近年来,生物合成技术在手性医药化学品合成关键酶的选择、催化机制解析、光学纯手性中间体合成途径构建、工艺开发及放大生产等方面均取得长足进步,有望解决手性中心构筑复杂、光学纯度低、污染大等手性化学品制造的瓶颈问题,推动我国医药行业的绿色可持续发展。本文主要总结了中国科学院天津工业生物技术研究所成立以来在手性医药化学品生物催化合成方面的一些研究进展。In nature,chirality is a common phenomenon and closely related to life,also significantly influences the properties of the substance.The chemical synthesis of chiral pharmaceutical chemicals has encountered challenges such as poor atom economy and process economy,serious environmental pollution and waste of the resource.The biosynthesis route has the advantages of high selectivity and environmental-friendliness.In recent years,the rapid developments in the accessible key enzymes,understanding of catalytic mechanism,construction of new synthetic pathways of optical pure intermediates,process development and scale-up production have made it possible to address the challenges encountered in the production of active pharmaceutical ingredients,thus promoting a green and sustainable pharmaceutical industry in China.This review summarized the achievements made in this field by researchers at Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences.

关 键 词：光学纯化合物 医药化学品 酶催化 生物合成 

分 类 号：TQ460.6[化学工程—制药化工]