恶性胶质瘤免疫治疗的研究进展  

Current state of immunotherapy in malignant glioma

作　　者：王一楠[1,2,3] 杨晓波 袁千惠[2] 舒晓宏 WANG Yinan;YANG Xiaobo;YUAN Qianhui;SHU Xiaohong(Institute of Integrative Medicine,Dalian Medical University,Dalian 116044,China;College of Pharmacy,Dalian Medical University,Dalian 116044,China;GCP Office,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China)

机构地区：[1]大连医科大学中西医结合研究院,辽宁大连116044 [2]大连医科大学药学院,辽宁大连116044 [3]大连医科大学附属第一医院临床试验机构办公室,辽宁大连116011

出　　处：《大连医科大学学报》2022年第5期425-432,共8页Journal of Dalian Medical University

基　　金：国家自然科学基金项目(81672945,81502992);辽宁省教育厅项目(LJKZ0827)。

摘　　要：恶性胶质瘤是中枢神经系统常见的原发性脑肿瘤,具有恶性程度高、致死率高、致残率高和复发率高等特点。目前,临床治疗主要采用手术切除,并结合放、化疗等多种治疗手段。但恶性胶质瘤在颅内重要功能区常呈浸润式生长,手术难以彻底切除而易复发,加之血脑屏障的存在,不仅极大地降低化疗药物的疗效,而且影响肿瘤细胞对凋亡信号的应答,导致患者几乎不可治愈。免疫治疗的出现,加深了人们对大脑免疫微环境与机体免疫系统之间关系的认识,为胶质瘤治疗开辟了新的途径,并有望提升患者的生存获益。本文将对恶性胶质瘤的主动免疫和被动免疫的治疗策略及研究进展,包括肿瘤疫苗、免疫检查点抑制剂和过继性细胞免疫治疗等加以综述。Malignant glioma,one of the most common primary tumors of the central nervous system,has the characteristics of high malignancy,high mortality rate,high disability rate and high recurrence rate.For decades,conventional therapies,including surgical resection,radiotherapy and chemotherapy,have not resulted in major improvements in the survival outcomes of patients with high-grade glioma,especially for glioblastoma.Reasons for this lack of efficacy include invasive tumor growth in brain tissue,which limits the utility of local therapy,as well as protection of tumor cells by the blood-brain barrier,which not only greatly reduce the efficacy of therapeutic drugs,but also increase their intrinsic resistance to the induction of cell death,imposing challenges for effective therapy.The emergence of immunotherapy has enhanced the understanding of the relationship between the immune microenvironment in central nervous system and the whole immune system,which provides more novel treatment options for glioma and has been achieving some exciting results.This review introduces the strategies and latest progress of active and passive immunotherapies for glioma including vaccination strategies,check point blockade and adoptive T cell therapies.

关 键 词：恶性胶质瘤 免疫治疗 主动免疫治疗 被动免疫治疗 免疫检查点抑制剂 

分 类 号：R739.41[医药卫生—肿瘤]