急性脑梗死合并2型糖尿病患者血清ALCAM、PECAM-1水平与颈动脉斑块稳定性的关系  

Relationship of Carotid Plaque Stability with Serum ALCAM and PECAM-1 in Patients with Acute Cerebral Infarction and Type 2 Diabetes Mellitus

作　　者：孙秀娟 雷光锋 SUN Xiu-juan;LEI Guang-feng(Department of Neurology,Huayin People's Hospital,Weinan Shaanxi 714200)

机构地区：[1]华阴市人民医院神经内科,陕西渭南714200 [2]渭南市第二医院老年病科,陕西渭南714000

出　　处：《医学临床研究》2022年第10期1535-1538,共4页Journal of Clinical Research

摘　　要：【目的】探讨急性脑梗死合并2型糖尿病患者血清活化白细胞黏附分子(ALCAM)、血小板内皮细胞黏附分子-1(PECAM-1)水平与颈动脉斑块稳定性的关系。【方法】选择在两院住院确诊的急性脑梗死合并2型糖尿病患者80例(观察组),另选取同期本院住院确诊的65例不伴2型糖尿病的急性脑梗死患者(对照组)。比较两组患者ALCAM、PECAM-1的水平,观察急性脑梗死合并2型糖尿病患者ALCAM、PECAM-1与颈动脉斑块稳定性和内部血管形成分级的关系。采用Pearson相关分析法分析ALCAM、PECAM-1与急性脑梗死合并2型糖尿病患者美国国立卫生院卒中量表(NIHSS)评分的关系。【结果】观察组ALCAM、PECAM-1水平均高于对照组(P<0.05)。观察组80例患者中无斑块11例,稳定斑块24例,不稳定斑块45例;无斑块患者ALCAM、PECAM-1水平低于稳定斑块患者和不稳定斑块患者(P<0.05),稳定斑块患者ALCAM、PECAM-1水平低于不稳定斑块患者(P<0.05)。80例患者中颈动脉斑块内部血管形成分级为0~1级的患者39例,2~3级患者41例,其中0~1级患者ALCAM、PECAM-1水平低于2~3级患者(P<0.05)。急性脑梗死合并2型糖尿病患者ALCAM、PECAM-1水平与NIHSS评分均呈正相关(均P<0.05)。【结论】ALCAM、PECAM-1在急性脑梗死合并2型糖尿病患者血清中的表达水平明显升高,其不仅与颈动脉斑块的稳定性、内部血管形成分级密切相关,还与患者神经功能受损程度呈显著正相关,临床应引起重视。【Objective】To investigate the relationship of carotid plaque stability with serum levels of activated leukocyte cell adhesion molecule(ALCAM)and platelet endothelial cell adhesion molecule-1(PECAM-1)in patients with acute cerebral infarction complicated with type 2 diabetes mellitus.【Methods】A total of 80 patients with acute cerebral infarction complicated with type 2 diabetes diagnosed in our hospital were selected as the observation group,while 65 acute cerebral infarction patients without type 2 diabetes in our hospital in the same period were selected as the control group.The levels of ALCAM and PECAM-1 were detected and compared between the two groups,and the relationship of carotid plaque stability and internal vessel formation grade with ALCAM and PECAM-1 in patients with acute cerebral infarction complicated with type 2 diabetes mellitus was analyzed.Pearson correlation analysis was used to analyze the relationship among ALCAM,PECAM-1 and NIHSS score in patients with acute cerebral infarction complicated with type 2 diabetes mellitus.【Results】The levels of ALCAM and PECAM-1 in the observation group were higher than those in the control group(all P<0.05).In the observation group,there were 11 cases without plaque,24 cases with stable plaque and 45 cases with unstable plaque.The levels of ALCAM and PECAM-1 in patients without plaque were lower than those in patients with stable plaque and unstable plaque(all P<0.05),and the levels of ALCAM and PECAM-1 in patients with stable plaque were lower than those in patients with unstable plaque(all P<0.05).Among the 80 patients,39 patients had carotid plaque internal vascularization grade of 0~1 and 41 patients had grade 2~3.The levels of ALCAM and PECAM-1 in grade 0~1 patients were lower than those in grade 2~3 patients(all P<0.05).The levels of ALCAM and PECAM-1 were positively correlated with NIHSS score in patients with acute cerebral infarction complicated with type 2 diabetes mellitus(all P<0.05).【Conclusion】Serum levels of ALCAM and PECAM-1 in

关 键 词：脑梗死/并发症 糖尿病/并发症 活化白细胞黏附分子/血液 血小板内皮细胞黏附分子1/血液 斑块 动脉粥样硬化 

分 类 号：R743.33[医药卫生—神经病学与精神病学]