Atropoenantioselective synthesis of heterobiaryl N-oxides via dynamic kinetic resolution  

作　　者：Xi Yuan Jian Wang 

机构地区：[1]College of Chemistry and Materials Science,Anhui Normal University,Wuhu,241002,China [2]School of Pharmaceutical Sciences,Tsinghua University,Beijing,100084,China

出　　处：《Science China Chemistry》2022年第12期2512-2516,共5页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21871160,21672121,22071130);the fellowship of Tsinghua-Peking Centre for Life Sciences(CLS).

摘　　要：A highly efficient enantioselective construction of heterobiaryl N-oxides was developed.A series of axially chiral heterobiaryl N-oxides were generated via the cascade reaction of aminobenzamides with heterobiaryl aldehydes in the presence of chiral phosphoric acids.A number of atropisomers were afforded in moderate to good yields with excellent enantioselectivities and diastereoselectivities.Preliminary results demonstrate that the heterobiaryl N-oxides can be utilized as efficient chiral ligands in asymmetric catalysis.

关 键 词：heterobiaryl N-oxides dynamic kinetic resolution chiral phosphoric acids atroposelectivity ORGANOCATALYSIS 

分 类 号：O641.4[理学—物理化学]