巨噬细胞耗竭及其在肝损伤中的应用  

Macrophage depletion and its application in liver injury

作　　者：于倩 赵赛[1] 刘亮明[1] YU Qian;ZHAO Sai;LIU Liangming(Songjiang Hospital Affiliated to Nanjing Medical University,Shanghai 201615,China)

机构地区：[1]南京医科大学上海松江临床医学院,上海201615

出　　处：《临床肝胆病杂志》2022年第12期2859-2863,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81770612)。

摘　　要：巨噬细胞是一种异质性细胞群,参与组织稳态、炎症和各种病理生理过程。巨噬细胞选择性地体内清除是一种被广泛接受的方法,用于研究巨噬细胞是否参与任何特定的生物学调控机制。了解不同巨噬细胞耗竭的方法及原理有助于探索研究巨噬细胞和疾病关系的合适的建模方案。肝巨噬细胞在肝毒性中起着至关重要的作用。本文就巨噬细胞耗竭的方法及巨噬细胞耗竭后在肝损伤和修复中的调节作用进行综述。Macrophages are a heterogeneous cell population involved in tissue homeostasis,inflammation,and various pathophysiological processes.Selective clearance of macrophages in vivo is a widely accepted method used to investigate whether macrophages are involved in any specific biological regulatory mechanism.Understanding the different methods and principles of macrophage depletion helps explore appropriate modeling solutions to investigate the relationship between macrophages and diseases.Hepatic macrophages play a crucial role in hepatotoxicity.This article reviews the methods of macrophage depletion and the regulatory role of macrophage depletion in liver injury and repair.

关 键 词：枯否细胞 巨噬细胞 肝损伤 

分 类 号：R575[医药卫生—消化系统]