microRNA在血管性认知损害中的分子机制研究进展  

Advances in Molecular Mechanisms of microRNA in Vascular Cognitive Impairment

作　　者：李方 马英[1] LI Fang;MA Ying(Department of Neurology,the Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院神经内科,南充市637000

出　　处：《中国临床神经科学》2022年第5期590-594,共5页Chinese Journal of Clinical Neurosciences

基　　金：南充市研发资金项目(编号:NSMC20170427);南充市川北医学院校级科研项目(编号:CBY21-QA50)。

摘　　要：血管性认知损害(VCI)是由各种脑血管病或其危险因素引起的不同程度认知损害的临床综合征。随着全球老龄化程度的不断加重,VCI发病率也与日俱增,但VCI的发病机制尚不明确,因而缺乏有效的治疗策略。微小RNA(microRNA,micRNA)是一类转录后靶向调控基因表达的非编码小RNA,参与众多疾病的发生发展,在VCI发病机制中亦发挥重要作用。文中就miRNA在VCI突触可塑性、炎症反应、血脑屏障通透性及神经元死亡等不同分子机制进行综述。Vascular cognitive impairment(VCI)is a clinical syndrome of cognitive impairment caused by various cerebrovascular diseases or their risk factors.With the aggravation of global aging,the incidence of VCI is also increasing.However,the specific pathogenesis of VCI is not clear at present,so there is a lack of effective treatment strategies.microRNA(miRNA),involved in the occurrence and development of many diseases,are a class of small non-coding RNA,which regulate gene expression after transcription,play an important role in the pathogenesis of VCI.The different molecular mechanisms including synaptic plasticity,inflammation,blood-brain barrier permeability,and neuronal death regulated through miRNA in VCI were reviewed.

关 键 词：MICRORNA 血管性认知损害 分子机制 

分 类 号：R743[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]