外泌体治疗缺血性脑卒中的研究进展  

Research Progress of Exosomes in the Treatment of Ischemic Stroke

作　　者：贾飞鸿 范学慧 钟镝[1] 李国忠[1] 赵秀丽[1] JIA Fei-hong;FAN Xue-hui;ZHONG Di;LI Guo-zhong;ZHAO Xiu-li(Department of Neurology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,哈尔滨150001

出　　处：《中国临床神经科学》2022年第5期595-600,共6页Chinese Journal of Clinical Neurosciences

基　　金：哈医大一院科研基金(编号:2011BS012)。

摘　　要：缺血性脑卒中是当前全球第二大致死原因,也是患者致残的主要病因,并且中国的缺血性脑卒中发病率逐年上升。近十年研究发现,天然生物来源的细胞外囊泡可以运载核酸、蛋白质及脂质等物质进行有效的细胞间信息交流。外泌体作为细胞外囊泡中特殊的一种类型,能够容纳和转移生物活性物质,有效穿越血脑屏障,可作为缺血性脑卒中的生物标志物及药物载体。文中对外泌体治疗缺血性脑卒中的研究进展进行综述。Ischemic stroke is the second leading cause of death and disability in the world,and its incidence is increasing year by year in China.Studies in the past decade have found that extracellular vesicles of natural biological origin can carry nucleic acids,proteins,lipids and other substances to carry out effective information communication between cells.Exosomes,as a special type of extracellular vesicles,can accommodate and transfer bioactive substances,effectively cross the blood-brain barrier,and can be used as biomarkers and drug carriers for ischemic stroke.The research progress of exosomes in the treatment of ischemic stroke were reviewed.

关 键 词：缺血性脑卒中 外泌体 间充质干细胞 治疗 

分 类 号：R743[医药卫生—神经病学与精神病学]