运动调节星形胶质细胞改善阿尔茨海默病机制研究  

Mechanism of Improved Function of Astrocytes in Alzheimer’s Disease Mediated by Physical Activity

作　　者：杜荔娟 吴璨 谢黄泽 徐佳挺 牛艳芳[1] 薛阳 王钦文[3] 周迎松[2] 徐淑君 DU Li-Juan;WU Can;XIE Huang-Ze;XU Jia-Ting;NIU Yan-Fang;XUE Yang;WANG Qin-Wen;ZHOU Ying-Song;XU Shu-Jun(Department of Neurology,the Affiliated Hospital of Medical School,Ningbo University,Ningbo 315020,China;Faculty of Physical Education,Ningbo University,Ningbo 315211,China;Zhejiang Provincial Key Laboratory of Pathophysiology,School of Medicine,Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学医学院附属医院脑科中心,宁波315020 [2]宁波大学体育学院,宁波315211 [3]浙江省病理生理学重点实验室,宁波大学医学院,宁波315211

出　　处：《生物化学与生物物理进展》2022年第11期2156-2164,共9页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81771166);宁波市科技局计划项目(202002N3165);宁波市研发计划重点项目(2022Z147);宁波市自然科学基金(2021J250);宁波大学研究生科研创新基金(SC2022178);宁波大学王宽诚幸福基金资助。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是老年人中最常见的中枢神经系统退行性疾病之一,AD的病理性改变与星形胶质细胞(astrocytes)密切相关。星形胶质细胞是血脑屏障和三方突触的重要组成部分。越来越多的证据表明,在AD早期阶段星形胶质细胞已出现分子和细胞水平的改变。星形胶质细胞的功能会影响AD的发生发展。多项研究表明,运动可以通过调节星形胶质细胞的激活、营养因子的释放、能量代谢、炎症及氧化应激反应,延缓AD的病理变化及改善AD认知功能障碍。本文对运动通过星形胶质细胞改善AD认知功能障碍的作用及机制进行综述和展望,旨在为AD的预防和治疗提供新策略。Alzheimer’s disease(AD)is an unremitting neurodegenerative disorder.Astrocytes play a fundamental role in maintaining the health and function of the central nervous system and memory.The pathological changes in brain of AD are closely related to astrocytes.Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in AD.Physical activity can effectively relieve cognitive impairment by regulating astrocytes in AD.In this review,we have summarized the multiple improvement effects on AD by physical activity through the regulation of astrocytes,including improving cell morphology and regulating astrocytes activation,increasing the release of trophic factors,regulating astrocytes phenotype and reducing neuroinflammation,improving glucose and lactate transportation in the brain as well as degrading oxidative stress.The knowledge of this review will pave the way for the prevent and treatment of AD through understanding the mechanisms of the beneficial effects mediated by physical activity through regulating astrocytes in AD.

关 键 词：阿尔茨海默病 星形胶质细胞 运动 认知功能障碍 

分 类 号：R74[医药卫生—神经病学与精神病学] G84[医药卫生—临床医学]