急性脑梗死患者早期血清可溶性肿瘤坏死因子样弱凋亡诱导剂水平与脑白质病变的相关性  

Correlation between the level of soluble tumor necrosis factor-like weak apoptotic inducer and white matter lesions in patients with acute cerebral infarction

作　　者：卜一 窦志杰[1] 张硕 钱旭东 王红梅[1] 杨康梅[1] BU Yi;DOU Zhi-jie;ZHANG Shuo(Depatment of Neurology,Affiliated Hospital of Chengde Medical College,Chengde Hebei 067000,China)

机构地区：[1]承德医学院附属医院神经内科,河北承德067000

出　　处：《临床和实验医学杂志》2022年第22期2368-2370,共3页Journal of Clinical and Experimental Medicine

基　　金：河北省科学技术研究与发展计划项目(编号:201904A100)。

摘　　要：目的研究急性脑梗死(ACI)患者早期血清可溶性肿瘤坏死因子样弱凋亡诱导剂(sTWEAK)水平与脑白质病变(WMLs)的相关性。方法采用回顾性分析方法,选取2019年6月至2021年12月承德医学院附属医院神经内科收治的80例ACI患者为观察对象,参考Fazekas量表评分分为A组(n=20,无WMLs)、B组(n=20,轻度WMLs)、C组(n=20,中度WMLs)、D组(n=20,重度WMLs)。记录并比较记录4组患者的一般资料(年龄、性别、冠心病史、糖尿病史、高血压病史、Fazekas评分),同时比较4组患者sTWEAK水平,对不同程度WMLs与sTWEAK水平之间的关系进行分析。结果4组患者性别构成比,冠心病、糖尿病、高血压病史占比比较,差异均无统计学意义(P>0.05);4组患者年龄、Fazekas评分比较,差异均有统计学意义(P<0.05),且WMLs程度越高,年龄、Fazekas评分越高。A、B、C、D组患者sTWEAK水平分别为(82.73±28.24)、(127.78±41.65)、(202.79±7.49)、(303.98±9.03)pg/mL,差异有统计学意义(P<0.05),且WMLs程度越高,sTWEAK水平越高。Pearson相关性分析显示,WMLs程度评分与年龄、sTWEAK呈正相关(r=0.422、0.484,P<0.05)。结论ACI患者早期血清sTWEAK水平与WMLs具有显著相关性,sTWEAK水平随着WMLs程度增加而上升,监测sTWEAK水平有利于提升早期预测WMLs程度的精准性。Objective To investigate the correlation between the level of soluble tumor necrosis factor-like weak apoptotic inducer(sTWEAK)and white matter lesions(WMLs)in patients with acute cerebral infarction(ACI).Methods By retrospective analysis,80 patients with ACI admitted to the Department of Neurology,Affiliated Hospital of Chengde Medical College from June 2019 to December 2021 were selected as the observation subjects.According to Fazekas score,they were divided into group A(n=20,without WMLs),group B(n=20,mild WMLs),group C(n=20,moderate WMLs),and group D(n=20,severe WMLs).General information(age,gender,history of coronary heart disease,history of diabetes,history of hypertension,Fazekas score)of the four groups were recorded and compared.Meanwhile,sTWEAK levels of the four groups were compared,and the relationship between different degrees of WMLs and sTWEAK levels was analyzed.Results There were no significant differences in gender composition,coronary heart disease,diabetes and hypertension history among the four groups(P>0.05);there was significant difference in age,Fazekas score among the four groups(P<0.05),and with the higher the level of WMLs,the higher the age and Fazekas score.The levels of sTWEAK in groups A,B,C,and D were(82.73±28.24),(127.78±41.65),(202.79±7.49),and(303.98±9.03)pg/mL,respectively,the differences were statistically significant(P<0.05),and the higher the degree of WMLs,the higher the sTWEAK level.Pearson correlation analysis showed that WMLs degree score was positively correlated with age and sTWEAK(r=0.422,0.484,P<0.05).Conclusion The serum sTWEAK level of ACI patients in early stage is significantly correlated with WMLs,and the sTWEAK level increases with the increase of WMLs degree.Monitoring sTWEAK level is beneficial to improve the accuracy of early prediction of WMLs degree.

关 键 词：急性脑梗死 脑白质病变 可溶性肿瘤坏死因子样弱凋亡诱导剂 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]