A deeper understanding of the gut microbiota of different human races in search of disease specific microbial and metabolic biomarkers  

作　　者：Sohini Mukhopadhyay Tanya Pattnaik Palok Aich 

机构地区：[1]School of Biological Sciences,National Institute of Science Education and Research(NISER),Odisha 751001,India [2]Homi Bhabha National Institute,Training School Complex,Anushakti Nagar,Mumbai 400094,India

出　　处：《Microenvironment & Microecology Research》2022年第4期7-24,共18页微环境与微生态学研究（英文）

摘　　要：Objective:Resident microorganisms live in dynamic harmony with their hosts to influence various physical and psychological health aspects.The majority of the resident microbes are found in the digestive tract,aka the gut of mammals.If and when perturbed,the composition of gut microbiota could jeopardize the physiological balance or homeostasis.In this article,we aim to establish how different diseases could be accompanied by notable changes in gut microbial composition and lend insight into microbial regulation of health.Methods:Literature search was done in PubMed using relevant keywords and summarized in tabular form as well as in narration.Results:We try to focus on the concept of microbial and metabolite biomarkers for diseases.We also try to capture the renewed perspective of good and harmful microorganisms in the context of host health.We have presented a comparative network analysis of microbial roles in select diseases.Recent findings also suggested that the growth of some traditionally disease-causing pathogenic microorganisms promotes health in other human communities.We have listed major taxa of gut microbes in communities worldwide,which signifies that gut microbiota can be healthy or harmful depending on the urbanization and ethnicity of the hosts.The traditional and current schools of thoughts are both limited by the technology of metagenomic studies;we have elucidated some of their shortcomings.Conclusion:Research in the field of gut microbiota must take into account the different populations and the changing narrative of healthy and harmful microbes.

关 键 词：diseases and biomarkers glitches of metagenomic approaches gut microbiota metabolic profiles urbanised and traditional gut microbiota 

分 类 号：R57[医药卫生—消化系统]