释氟充填材料在龋病防治中的研究进展  

Research progress on fluoride⁃releasing restorative materials for caries control

作　　者：寿宇珂 任彪[2] 程磊[1] SHOU Yuke;REN Biao;CHENG Lei(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&De-partment of Operative Dentistry and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科,四川成都610041 [2]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院,四川成都610041

出　　处：《口腔疾病防治》2023年第4期301-304,共4页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金面上项目(81870759);四川省科技计划资助项(2020YJ0227)。

摘　　要：传统玻璃离子水门汀、树脂增强型玻璃离子水门汀、聚酸改性复合树脂、Giomer等牙科充填修复材料具有氟离子释放和再充氟能力,被认为可以预防或减缓龋病的进展。释氟充填材料的释氟能力、抗菌性、力学特性及抗老化特性都是评价其防龋能力的重要指标,材料的防龋作用主要依赖于氟离子对矿化的影响。但是,释氟能力强的材料如传统玻璃离子水门汀因力学性能欠佳等劣势主要用于儿童牙科及暂时修复,材料的氟离子释放潜力和机械强度很难两全,尚未有材料可以在提供理想机械强度的同时释放大量氟离子。传统玻璃离子水门汀、树脂增强型玻璃离子水门汀、聚酸改性复合树脂、Giomer的氟离子释放和再充氟能力依次递减,材料改性的趋势倾向于为维持理想的机械强度,一定程度上牺牲材料释放氟离子的能力。目前研究者们尝试通过添加多种无机填料进一步增强材料的抗折裂能力,通过添加抗菌剂补偿材料因氟离子释放减少损失的防龋作用。Restorative materials such as conventional glass ionomer cement(CGIC),resin⁃modified glass ionomer ce⁃ment(RMGIC),polyacid⁃modified composite resin(compomer),and giomer have the properties of fluoride release and refill,which may prevent or slow down the progression of caries.The caries resistance of these materials was evaluated according to the following criteria:fluorine⁃releasing ability,antibacterial activity,mechanical properties and anti⁃aging properties.The anti⁃caries effect of these materials mainly depends on the effect of fluoride ions on mineralization.How⁃ever,materials with strong fluorine release ability,such as CGIC,are mainly used in pediatric dentistry and temporary restoration due to their poor mechanical properties.It is difficult to achieve both fluoride ion release potential and me⁃chanical strength,and there are few materials that can provide ideal mechanical strength while maintaining a high stan⁃dard of fluoride release.The fluoride releasing and recharging capacity of CGIC,RMGIC,compomer and giomer de⁃crease successively.The trend of material modification,to a certain extent,tends to sacrifice the fluoride release capaci⁃ty of materials to maintain the ideal mechanical strength.In recent years,scholars have tried to add a variety of fillers to further enhance the anti⁃cracking ability of materials and add antibacterial agents to compensate for the anti⁃caries ef⁃fect to reduce the loss of fluoride release.

关 键 词：释氟充填材料 防龋能力 玻璃离子水门汀 龋病 充填 牙科材料 窝沟封闭 材料改性 

分 类 号：R78[医药卫生—口腔医学]