血清VEGF、IL-6、CRP对中晚期NSCLC患者的诊断价值研究  

Diagnostic value of serum VEGF, IL-6 and CRP in patients with moderate to advanced NSCLC

作　　者：王歌平 李君艳[2] 马晓 王珍珍 陈国荣[2] WANG Ge-ping;LI Jun-yan;MA Xiao(Third Clinical College of Xinxiang Medical University,Xinxiang 453000,China)

机构地区：[1]新乡医学院第三临床学院,453000 [2]新乡医学院第三附属医院肿瘤内二科,453000

出　　处：《中国实用医药》2022年第25期14-17,共4页China Practical Medicine

基　　金：河南省新乡市科技攻关项目(项目编号:GG2019044)。

摘　　要：目的 探讨血管内皮生长因子(VEGF)、白细胞介素-6(L-6)、C反应蛋白(CRP)对中晚期非小细胞肺癌(NSCLC)的诊断价值,旨在为中晚期NSCLC尽早发现和及时诊断提供帮助。方法 选取80例初诊中晚期NSCLC患者作为观察组,另选取50例体检健康者作为对照组。两组均采用化学发光免疫法检测VEGF水平,采用电化学发光免疫法检测IL-6水平,采用免疫比浊法检测CRP水平。比较两组研究对象血清VEGF、IL-6、CRP水平,分析VEGF、IL-6、CRP单项及联合检测的受试者工作特征曲线(ROC曲线),比较血清VEGF、IL-6、CRP单项及联合检测的诊断效能。结果 观察组VEGF、IL-6和CRP水平分别为(259.83±131.73)pg/ml、(15.54±11.37)pg/ml、(13.55±12.41)mg/L,均高于对照组的(104.50±51.08)pg/ml、(5.84±1.91)pg/ml、(2.37±2.19)mg/L,差异有统计学意义(P<0.05)。VEGF+IL-6+CRP检测的灵敏度、特异度均优于VEGF、IL-6、CRP单项检测及VEGF+IL-6、VEGF+CRP、IL-6+CRP检测,差异有统计学意义(P<0.05)。结论 联合检测VEGF、IL-6和CRP水平对及时诊断中晚期NSCLC具有重要的临床意义,可用于早期NSCLC的筛查和诊断,有助于制定个体化用药方案,改善预后。Objective To discuss the diagnostic value of vascular endothelial growth factor(VEGF),interleukin-6(IL-6), C-reactive protein(CRP) in patients with moderate to advanced non-small cell lung cancer(NSCLC), so as to provide help for early detection and timely diagnosis of moderate to advanced NSCLC.Methods 80 patients with primary diagnosis of moderate to advanced NSCLC were selected as the observation group, and another 50 healthy individuals with physical examination were selected as the control group. Both groups used chemiluminescence immunoassay to detect VEGF level, electrochemiluminescence immunoassay to detect IL-6 level, and immunoturbidimetric assay to detect CRP level. Serum VEGF, IL-6 and CRP levels were compared between the two groups, and the receiver operating characteristic(ROC) curves of single and combined detection of VEGF, IL-6, and CRP were analyzed to compare the diagnostic efficacy of single and combined detection of VEGF, IL-6, and CRP. Results The levels of VEGF, IL-6 and CRP in the observation group were(259.83±131.73) pg/ml,(15.54±11.37) pg/ml and(13.55±12.41) mg/L, which were higher than(104.50±51.08) pg/ml,(5.84±1.91) pg/ml, and(2.37±2.19) mg/L in the control group, the difference was statistically significant(P<0.05). The sensitivity and specificity of VEGF+IL-6+CRP detection were better than VEGF,IL-6, CRP single detection and VEGF+IL-6, VEGF+CRP, IL-6+CRP detection, and the differences were all statistically significant(P<0.05). Conclusion Combined detection of VEGF, IL-6 and CRP levels is of great significance for timely diagnosis of moderate to advanced NSCLC, which can be used for screening and diagnosis of early-stage NSCLC and help to develop individualized drug regimens and improve prognosis.

关 键 词：非小细胞肺癌 血管内皮生长因子 白细胞介素-6 C反应蛋白 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]