甲状腺生物学指标与甲状腺乳头状癌的关系  

Correlation between thyroid biological indicators and papillary thyroid carcinoma

作　　者：殷放[1] 邓琳[1] 翁泽滨[1] YIN Fang;DENG Lin;WENG Ze-bin(Department of Thyroid and Breast Surgery,Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China)

机构地区：[1]中山大学附属第五医院甲状腺乳腺外科,519000

出　　处：《中国实用医药》2022年第25期32-35,共4页China Practical Medicine

摘　　要：目的探讨甲状腺的主要生物学指标[促甲状腺素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)、甲状腺球蛋白(Tg)、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))]与甲状腺乳头状癌的关系。方法回顾性分析850例甲状腺结节患者的临床资料,根据术后病理结果分为甲状腺乳头状癌组(530例)和甲状腺良性结节组(320例)。比较两组性别、年龄及甲状腺生物学指标(FT_(3)、FT_(4)、TPOAb、TSH、Tg、TgAb),甲状腺乳头状癌组中不同肿瘤直径及颈部淋巴结是否转移患者患者的甲状腺生物学指标。结果两组患者的性别、年龄、FT_(3)、FT_(4)、TPOAb比较差异无统计学意义(P>0.05)。甲状腺乳头状癌组患者的TSH、Tg、TgAb升高占比均高于甲状腺良性结节组,差异具有统计学意义(P<0.05)。甲状腺乳头状癌组中,96例患者的肿瘤直径>1.0 cm,434例患者的肿瘤直径≤1.0 cm。甲状腺乳头状癌组中肿瘤直径>1.0 cm患者的TSH(2.96±2.53)μIU/ml及Tg(44.85±11.06)ng/ml均高于肿瘤直径≤1.0 cm患者的(2.15±2.62)μIU/ml、(21.58±18.73)ng/ml,差异具有统计学意义(P<0.05);甲状腺乳头状癌组中肿瘤直径>1.0 cm患者的FT_(3)、FT_(4)、TPOAb、TgAb与肿瘤直径≤1.0 cm患者比较,差异无统计学意义(P>0.05)。甲状腺乳头状癌组中,285例患者无颈部淋巴结转移,245例患者伴有颈部淋巴结转移。甲状腺乳头状癌组中颈部淋巴结转移患者的Tg(31.98±10.53)ng/ml高于无颈部淋巴结转移患者的(20.27±12.46)ng/ml,差异具有统计学意义(P<0.05);甲状腺乳头状癌组中颈部淋巴结转移患者的FT_(3)、FT_(4)、TSH、TPOAb、TgAb与无颈部淋巴结转移患者比较,差异无统计学意义(P>0.05)。结论TSH、TGAb、Tg在甲状腺乳头状癌的临床病理特征的诊断中具有一定的指导意义。Objective To discuss the correlation between thyroid biological indicators[thyroid stimulating hormone (TSH),thyroid peroxidase antibody (TPOAb),thyroglobulin antibody (TgAb),thyroglobulin(Tg),free triiodothyronine (FT),free thyroxine (FT)]and papillary thyroid carcinoma.Methods The clinical data of 850 patients with thyroid nodules were retrospectively analyzed and divided into papillary thyroid carcinoma group (530 patients) and benign thyroid nodule group (320 patients) according to postoperative pathological findings.Comparison was made on gender,age and thyroid biological indexes (FT,FT,TPOAb,TSH,Tg,TgAb)between the two groups,as well as the thyroid biological indexes of patients with different tumor diameters and cervical lymph node metastasis in the papillary thyroid carcinoma group.Results There was no statistically significant difference in gender,age,FT,FTand TPOAb between the two groups (P>0.05).The elevated proportions of TSH,Tg and TgAb in the papillary thyroid carcinoma group were higher than those in the benign thyroid nodule group,and the difference was statistically significant (P<0.05).In the papillary thyroid carcinoma group,96 patients had tumors diameter>1.0 cm,and 434 patients had tumors diameter≤1.0 cm.In the papillary thyroid carcinoma group,the TSH (2.96±2.53)μIU/ml and Tg (44.85±11.06) ng/ml of patients with tumor diameter>1.0 cm were higher than (2.15±2.62)μIU/ml,(21.58±18.73) ng/ml of patients with tumor diameter≤1.0 cm,and the differences were statistically significant (P<0.05).In the papillary thyroid cancer group,FT,FT,TPOAb and TgAb in patients with tumor diameter>1.0 cm were not statistically significant compared with those in patients with tumor diameter≤1.0 cm (P>0.05).In the papillary thyroid carcinoma group,285 patients had no cervical lymph node metastases,and 245 patients had cervical lymph node metastases.In the papillary thyroid carcinoma group,the Tg of patients with cervical lymph node metastasis was (31.98±10.53) ng/ml,which was higher than (20.27±12.46) n

关 键 词：甲状腺乳头状癌 甲状腺球蛋白 甲状腺球蛋白抗体 促甲状腺素 

分 类 号：R736.1[医药卫生—肿瘤]