神经节苷脂联合依达拉奉治疗急性脑梗死的临床疗效分析  

Clinical efficacy analysis of ganglioside combined with edaravone in the treatment of acute cerebral infarction

作　　者：刘俊鸿 LIU Jun-hong(Department of Neurology,Lingyuan Central Hospital,Lingyuan 122500,China)

机构地区：[1]凌源市中心医院神经内科,122500

出　　处：《中国实用医药》2022年第25期119-121,共3页China Practical Medicine

摘　　要：目的 探究急性脑梗死(ACI)患者应用神经节苷脂与依达拉奉联合治疗的效果和安全性。方法 138例ACI患者,随机分为观察组与对照组,每组69例。对照组采用依达拉奉治疗,观察组采用神经节苷脂联合依达拉奉治疗。比较两组治疗效果、用药不良反应发生情况及治疗前后炎症因子[血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平。结果 观察组治疗总有效率94.20%高于对照组的79.71%,差异有统计学意义(P<0.05)。两组用药不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,观察组TNF-α(17.24±2.81)μg/L、CRP(14.33±1.59)mg/L、IL-6(20.84±3.64)ng/L均低于对照组的(22.38±2.98)μg/L、(19.68±1.85)mg/L、(30.16±3.96)ng/L,差异均有统计学意义(P<0.05)。结论 ACI患者采用神经节苷脂联合依达拉奉治疗临床疗效显著,可改善患者神经损伤,降低机体炎症水平,且用药不良反应少,值得推广。Objective To investigate the effect and safety of ganglioside combined with edaravone in the treatment of patients with acute cerebral infarction(ACI). Methods A total of 138 cases of ACI patients were randomly divided into an observation group and a control group, with 69 cases in each group. The control group was treated with edaravone, and the observation group was treated with ganglioside combined with edaravone. Both groups were compared in terms of therapeutic effect, the occurrence of adverse drug reactions, and the levels of inflammatory factors [serum tumor necrosis factor-α(TNF-α), C-reactive protein(CRP), and interleukin-6(IL-6)] before and after treatment. Results The total effective rate 94.20%of the observation group was higher than 79.71% of the control group, and the difference was statistically significant(P<0.05). There was no statistically significant difference in the incidence of adverse drug reactions between the two groups(P>0.05). After treatment, the TNF-α(17.24±2.81) μg/L, CRP(14.33±1.59) mg/L, and IL-6(20.84±3.64) ng/L in the observation group were all lower than(22.38±2.98) μg/L,(19.68±1.85) mg/L, and(30.16±3.96) ng/L in the control group, and the differences were all statistically significant(P<0.05). Conclusion The clinical effect of ganglioside combined with edaravone in the treatment of ACI is significant, which can improve the nerve injury of patients, reduce the level of inflammation, and has less adverse drug reactions, which is worthy of promotion.

关 键 词：急性脑梗死 神经节苷脂 依达拉奉 联合用药 临床疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]