银杏达莫注射液联合丁苯酞治疗急性脑梗死的临床观察  

Clinical observation of ginkgo leaf extract and dipyridamole injection combined with butylphthalide in the treatment of acute cerebral infarction

作　　者：朱来清[1] ZHU Lai-qing(Department of Pharmacy,Jining First People's Hospital,Jining 272111,China)

机构地区：[1]济宁市第一人民医院药剂科,272111

出　　处：《中国实用医药》2022年第24期113-115,共3页China Practical Medicine

摘　　要：目的探讨银杏达莫注射液联合丁苯酞治疗急性脑梗死(ACI)的疗效及安全性。方法96例ACI患者,随机分为联合组和对照组,各48例。所有患者均给予常规治疗,对照组同时给予丁苯酞注射液治疗,联合组在对照组基础上给予银杏达莫注射液治疗。比较两组患者临床疗效、治疗前后神经功能缺损情况、日常生活能力、不良反应发生情况。结果联合组治疗总有效率93.8%高于对照组的66.7%,差异具有统计学意义(P<0.05)。治疗后,两组患者美国国立卫生研究院卒中量表(NIHSS)评分均低于治疗前,Barthel指数(BI)评分高于治疗前,且联合组患者NIHSS评分(4.7±1.5)分低于对照组的(6.5±1.2)分,BI评分(83.6±29.6)分高于对照组的(57.7±27.2)分,差异均具有统计学意义(P<0.05)。联合组不良反应发生率6.3%低于对照组的29.2%,差异具有统计学意义(P<0.05)。结论银杏达莫注射液联合丁苯酞注射液治疗ACI能明显提高其整体疗效,改善患者神经功能,提高日常生活能力,且有较高的安全性。Objective To discuss the efficacy and safety of ginkgo leaf extract and dipyridamole injection combined with butylphthalide in the treatment of acute cerebral infarction(ACI).Methods A total of 96 patients with ACI were randomly divided into a combination group and a control group,with 48 cases in each group.All patients received conventional treatment.On this basis,the control group was treated with butylphthalide injection,and the combination group was treated with ginkgo leaf extract and dipyridamole injection based on the control group.The clinical efficacy,neurological deficit and activities of daily living before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment 93.8%of the combination group was higher than 66.7%of the control group,and the difference was statistically significant(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)scores in both groups were lower than those before treatment in this group,and the Barthel Index(BI)scores were higher than those before treatment in this group;the NIHSS score(4.7±1.5)points of the combination group was lower than(6.5±1.2)points of the control group;the BI score(83.6±29.6)points of the combination group was higher than(57.7±27.2)points of the control group;the differences were all statistically significant(P<0.05).The incidence of adverse reactions 6.3%in the combination group was lower than 29.2%in the control group,and the difference was statistically significant(P<0.05).Conclusion Ginkgo leaf extract and dipyridamole injection combined with butylphthalide can significantly improve the overall efficacy of ACI,improve patients'neurological function and enhance their activities of daily living,and has high safety.

关 键 词：银杏达莫注射液 丁苯酞 急性脑梗死 疗效 安全性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]