手术联合吉西他滨或吡柔比星膀胱灌注治疗老年膀胱癌的效果比较  

Comparison of the effect of surgery combined with gemcitabine or intravesical instillation of pirarubicin in the treatment of bladder cancer in the elderly

作　　者：刘鹏 LIU Peng(Panjin Central Hospital,Panjin 124010,China)

机构地区：[1]盘锦市中心医院,124010

出　　处：《中国实用医药》2022年第24期129-131,共3页China Practical Medicine

摘　　要：目的分析手术联合吉西他滨或吡柔比星膀胱灌注治疗老年膀胱癌的临床效果。方法88例老年膀胱癌患者,按照随机数字表法分为对照组和观察组,每组44例。对照组采取手术联合吡柔比星膀胱灌注治疗,观察组患者采取手术联合吉西他滨膀胱灌注治疗。比较两组治疗前后生活质量评分、功能状况评分、不良反应发生情况、术后复发情况。结果治疗后,观察组简明健康状况调查表(SF-36)评分(80.17±3.24)分、Karnofsky(KPS)评分(78.16±4.65)分高于对照组的(68.76±3.67)、(70.28±3.12)分,差异有统计学意义(P<0.05)。观察组不良反应发生率为4.55%,低于对照组的18.18%,差异有统计学意义(P<0.05)。观察组术后6个月复发率为2.27%,低于对照组的15.91%,差异有统计学意义(P<0.05)。观察组术后1年累计复发率为2.27%,低于对照组的18.18%,差异有统计学意义(P<0.05)。结论手术联合吉西他滨膀胱灌注效果显著优于吡柔比星,不但能够改善患者术后生活质量,还可以降低不良反应发生率及复发率。Objective To analyze the clinical effect of surgery combined with gemcitabine or intravesical instillation of pirarubicin in the treatment of bladder cancer in the elderly.Methods A total of 88 elderly patients with bladder cancer were divided into control group and observation group according to the random numerical table,with 44 cases in each group.The control group was treated with surgery combined with intravesical infusion of pirarubicin,while the observation group was treated with surgery combined with intravesical infusion of gemcitabine.The quality of life score and functional status score before and after treatment,incidence of adverse reactions and postoperative recurrence were compared between the two groups.Results After treatment,the 36-item short-form health survey(SF-36)score(80.17±3.24)points and Karnofsky performance scale(KPS)score(78.16±4.65)points in the observation group were higher than(68.76±3.67)and(70.28±3.12)points in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 4.55%,which was lower than 18.18%in the control group,and the difference was statistically significant(P<0.05).The recurrence rate 6 months after surgery in the observation group was 2.27%,which was lower than 15.91%in the control group,and the difference was statistically significant(P<0.05).The cumulative recurrence rate 1 year after surgery in the observation group was 2.27%,which was lower than 18.18%in the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of surgery combined with intravesical instillation of gemcitabine is significantly better than that of pirarubicin,which can not only improve the postoperative quality of life of patients,but also reduce the incidence of adverse reactions and recurrence rates.

关 键 词：吉西他滨 吡柔比星 膀胱灌注 老年膀胱癌 

分 类 号：R737.14[医药卫生—肿瘤]