胃癌患者外周血Cyttel循环肿瘤细胞的检测及临床意义  

Detection of Cyttel Circulating Tumor Cells in Peripheral Blood of Patients With Gastric Cancer and its Clinical Significance

作　　者：李娟娟[1] 张超[2] LI Juanjuan;ZHANG Chao(Department of Gastroenterology,the Second Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233040,China;Department of Oncology,the Second Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233040,China)

机构地区：[1]蚌埠医学院第二附属医院消化内科,安徽蚌埠233040 [2]蚌埠医学院第二附属医院肿瘤外科,安徽蚌埠233040

出　　处：《中国卫生标准管理》2022年第21期117-120,共4页China Health Standard Management

基　　金：蚌埠医学院校自然科学基金面上项目(BYKY18136)。

摘　　要：目的分析莱尔(Cyttel)检测法对胃癌患者外周血循环肿瘤细胞(circulating tumor cells,CTCs)的检测结果及临床意义。方法选取蚌埠医学院第二附属医院2019年1月—2021年1月收治的50例胃癌患者和胃部良性疾病患者40例作为研究组和对照组,均采用Cyttel法对其外周血CTCs进行检测,比较两组外周血CTCs阳性检出率,并分析外周血CTCs阳性与胃癌患者临床病理特征的关系。结果研究组外周血CTCs阳性率为72.00%,高于对照组的10.00%,差异有统计学意义(P<0.05)。研究组CTCs阳性与阴性患者的癌胚抗原(carcinoembryonic antigen,CEA)、脉管侵犯、糖类抗原19-9(carbohydrate antigen 19-9,CA19-9)及糖类抗原72-4(carbohydrate antigen 72-4,CA72-4)比较,差异有统计学意义(P<0.05)。结论Cyttel法对胃癌患者外周血CTCs具有较高检出率,动态监测外周血CTCs变化,有助于及早发现和预测胃癌患者的肿瘤转移情况。Objective To analyze the detection results and clinical significance of Cyttel assay for circulating tumor cells(CTCs)in patients with gastric cancer.Methods A total of 50 patients with gastric cancer and 40 patients with benign gastric diseases admitted to the Second Affiliated Hospital of Bengbu Medical College from January 2019 to January 2021 were selected as the study group and the control group.Their peripheral blood CTCs were detected by the Cyttel method.The positive detection rates of peripheral blood CTCs in the two groups were compared,and the relationship between the positive peripheral blood CTCs and the clinicopathological characteristics of gastric cancer patients was analyzed.Results The positive rate of peripheral blood CTCs in the study group was 72.00%,which was significantly higher than that in the control group(10.00%)(P<0.05).There were statistically significant differences between the positive and negative patients in the study group in terms of carcinoembryonic antigen(CEA),vascular invasion,carbohydrate antigen 19-9(CA19-9)and carbohydrate antigen 72-4(CA72-4)(P<0.05).Conclusion Cyttel method has a high detection rate of peripheral blood CTCs in patients with gastric cancer.Dynamic monitoring of the changes of peripheral blood CTCs is helpful for early detection and prediction of tumor metastasis in patients with gastric cancer.

关 键 词：Cyttel检测 胃癌 外周血 肿瘤细胞 循环肿瘤细胞阳性 肿瘤转移 

分 类 号：R735[医药卫生—肿瘤]