家族性乳腺癌及非家族性乳腺癌预后影响因素分析及健康管理建议  

Analysis of prognostic factors in familial breast cancer and non-familial breast cancer and suggestions for health management

作　　者：郑晓冬 徐樟玲 王文武[1] ZHENG Xiaodong;XU Zhangling;WANG Wenwu(Department of Breast and Nail Surgery,Quzhou People's Hospital,Zhejiang,Quzhou 324100,China;Department of Cardiothoracic Surgery,Quzhou Second People's Hospital,Zhejiang,Quzhou 324022,China)

机构地区：[1]衢州市人民医院乳甲外科,浙江衢州324100 [2]衢州市第二人民医院心胸外科,浙江衢州324022

出　　处：《中国现代医生》2022年第35期41-45,共5页China Modern Doctor

基　　金：衢州市科技局指导性科技攻关项目(2021027)。

摘　　要：目的分析家族性乳腺癌及非家族性乳腺癌预后影响因素,并提出健康管理建议。方法选取2019年3月至2021年1月衢州市人民医院收治的乳腺癌患者80例进行为期1年随访,根据问卷调查结果分为家族性乳腺癌组(n=26)及非家族性乳腺癌组(n=54);根据局部复发及远处转移情况,分为预后不良组(n=20)和预后良好组(n=60)。对影响预后效果的危险因素进行多因素Logistic分析。结果家族性乳腺癌组的腋窝淋巴结转移阳性占比高于非家族性乳腺癌组,差异有统计学意义(P<0.05)。两组的局部复发率及远处转移率相比,差异无统计学意义(P>0.05)。通过多因素Logistic回归分析显示,腋窝淋巴结阳性、未进行放化疗、临床分期(Ⅲ期)为引发乳腺癌患者预后不良的独立危险因素(P<0.05)。结论影响家族性/非家族性乳腺癌患者预后的危险因素较多,临床上根据这些危险因素制定针对性的管理策略,可能对改善患者预后有帮助。Objective To analyze the prognostic factors of familial breast cancer and non-familial breast cancer,and to propose health management suggestions.Methods A total of 80 breast cancer patients admitted to Quzhou People's Hospital from March 2019 to January 2021 were selected for a 1-year follow-up,and were divided into familial breast cancer group(n=26)and non-familial breast cancer group(n=54)according to the results of the questionnaire.Based on local recurrence and distant metastasis,the patients were divided into poor prognosis group(n=20)and good prognosis group(n=60),and a multifactorial Logistic analysis was performed to determine the risk factors affecting the prognosis outcome.Results The proportion of positive axillary lymph node metastasis in the familial breast cancer group was higher than that in the non-familial breast cancer group,and the difference was statistically significant(P<0.05).There was no difference in local recurrence rate and distant metastasis rate between the two groups(P>0.05).Multivariate Logistic regression analysis showed that positive axillary lymph nodes,no radiotherapy and chemotherapy,and clinical stage(Ⅲ)were independent risk factors for poor prognosis in breast cancer patients,and the differences were statistically significant(P<0.05).Conclusion There are many risk factors affecting the prognosis of patients with familial/non-family breast cancer.In clinical practice,targeted management strategies based on these risk factors may help improve the prognosis of patients.

关 键 词：健康管理 乳腺癌 非遗传性 影响因素 

分 类 号：R737.9[医药卫生—肿瘤]