奥曲肽联合注射用奥美拉唑在胃十二指肠溃疡出血患者中的应用效果  

Effect of octreotide combined with omeprazole for injection in patients with gastroduodenal ulcer bleeding

作　　者：谭晓娟 TAN Xiaojuan(Department of Gastroenterology,Yichun Zhegan Jiangxi Friendship Hospital,Jiangxi,Yichun 336000,China)

机构地区：[1]宜春浙赣友好医院消化内科,江西宜春336000

出　　处：《中国现代医生》2022年第35期110-113,118,共5页China Modern Doctor

摘　　要：目的探究奥曲肽联合注射用奥美拉唑在胃十二指肠溃疡出血患者中的应用效果。方法选取2021年8月至2022年2月宜春浙赣友好医院收治的胃十二指肠溃疡出血患者64例,采用随机数字表法分为对照组和观察组,每组32例。对照组给予注射用奥美拉唑治疗,观察组在对照组基础上加用奥曲肽治疗。比较两组患者临床疗效、血常规指标[血红蛋白(hemoglobin,Hb)、白细胞(white blood cell,WBC)计数、血红细胞(red blood cell,RBC)计数、血小板(platelet,PLT)计数、血细胞比容(hematocrit,HCT)]、凝血功能指标[凝血酶原时间(prothrombin time,PT)、凝血酶时间(thrombin time,TT)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、纤维蛋白原(fibrinogen,Fib)]、胃相关指标(胃液pH值水平、促胃液素)、炎症因子水平[白介素(interleukin,IL)-2、IL-6及IL-17]及不良反应。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组Hb、RBC、PLT、HCT水平均高于对照组,差异有统计学意义(P<0.05);观察组PT、TT、APTT、Fib水平均优于对照组,差异有统计学意义(P<0.05);观察组胃液pH值高于对照组,促胃液素水平低于对照组,差异有统计学意义(P<0.05);观察组IL-2、IL-6、IL-17水平均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论治疗胃十二指肠溃疡出血采用奥曲肽联合注射用奥美拉唑可提高临床疗效,有效改善患者胃液pH值与促胃液素水平,改善血常规和凝血功能指标,利于减轻炎症,促进机体恢复,临床应用安全、可行,值得推广运用。Objective To explore the effect of octreotide combined with omeprazole for injection in patients with gastroduodenal ulcer bleeding.Methods A total of 64 patients with gastroduodenal ulcer bleeding admitted to Yichun Zhegan Jiangxi Friendship Hospital from August 2021 to February 2022 were included.They were divided into two groups according to the random number table,with 32 patients in each group.The control group was treated with omeprazole for injection.On this basis,the observation group was treated with octreotide.The clinical efficacy,blood routine index[hemoglobin(Hb),white blood cell(WBC)count,red blood cell(RBC)count,platelet(PLT)count,hematocrit(HCT)],coagulation function index[prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(Fib)],gastric related index(gastric juice pH level,gastrin),inflammatory factor level[interleukin-2(IL-2),interleukin-6(IL-6)and interleukin-17(IL-17)]and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of Hb,RBC,PLT in the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).The levels of PT,TT and APTT in the observation group were better than those in the control group after treatment,and the differences were statistically significant(P<0.05).The pH value of gastric juice in the observation group was higher than that in the control group after treatment,the level of gastrin was lower than that of the control group,and the differences were statistically significant(P<0.05).The levels of IL-2,IL-6 and IL-17 in the observation group were lower than those in the control group after treatment,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Octreotide combined

关 键 词：胃十二指肠溃疡出血 注射用奥美拉唑 奥曲肽 炎症因子 凝血功能 

分 类 号：R573.1[医药卫生—消化系统]