乳腺癌X线边缘毛刺征、边缘分叶征与患者生物学因子水平及分子分型的关系  

Relationship Between X-Ray Edge Burr Sign,Edge Lobulation Sign and Biological Factors and Molecular Typing of Breast Cancer Patients

作　　者：左玮玮 齐赛 刘一航 ZUO Weiwei;QI Sai;LIU Yihang(Department of Radiology,Xingtai Third Hospital,Xingtai Hebei 054000,China)

机构地区：[1]邢台市第三医院放射科,河北邢台054000

出　　处：《中国医疗设备》2022年第12期82-86,共5页China Medical Devices

基　　金：邢台市科技计划项目(2018ZC107)。

摘　　要：目的研究乳腺癌X线边缘毛刺征、边缘分叶征与患者生物学因子水平及分子分型的关系。方法选取2018年4月至2021年9月本院收治的233例乳腺癌患者为研究对象,所有患者均行切除术,并经术后病理组织活检证实,行免疫组化法测定雌激素受体(Estrogen Receptor,ER)、孕激素受体(Progesterone Receptor,PR)、人类上皮生长因子-2(Human Epidermal Growth Factor-2,Her-2)、Ki-67和p53水平,分析乳腺癌X线毛刺和分叶征象,以及分析乳腺X线摄影术边缘征象与分子分型和生物学因子的相关性。结果233例乳腺癌患者中,Luminal A型51例,Luminal B型114例,HER-2过表达型39例和三阴型29例,不同分子分型的边缘毛刺征象差异有统计学意义(χ2=67.032,P<0.001),Luminal A型和Luminal B型中乳腺癌毛刺表达率较高。不同分子分型边缘分叶征象差异有统计学意义(χ2=14.849,P=0.002),Luminal B型和三阴型中乳腺癌分叶征象表达率较高。边缘毛刺征象与ER和PR阳性表达率相关;边缘分叶征象与ER和HER-2阳性表达率相关。乳腺癌X线边缘毛刺征象与ER和PR阳线表达由弱到强的分布趋势存在明显关系。乳腺癌X线边缘分叶征象与ER阳性表达由弱到强的分布趋势存在明显关系。结论乳腺癌X线边缘毛刺征象与Luminal A和Luminal B分子分型直接相关,而无毛刺征象多出现在三阴型乳腺癌;分叶征象可用于判断Luminal B型和三阴型,且毛刺和分叶征象与生物学因子阳性表达相关,临床X线摄影术可在一定程度上预测乳腺癌组织的生物学因子表达情况。Objective To study the relationship between X-ray edge burr sign,edge lobed sign and the level of biological factors and molecular typing of breast cancer patients.Methods A total of 233 breast cancer patients admitted to our hospital from April 2018 to September 2021 were selected.All patients underwent resection and confirmed by postoperative pathological biopsy.The levels of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor-2(Her-2),Ki-67 and p53 were measured by immunohistochemical method,and the X-ray burr and lobulation signs of breast cancer were analyzed,and the correlation between the marginal signs of mammography and molecular typing and biological factors was analyzed.Results Among 233 cases of breast cancer patients,51 cases were Luminal A type,114 cases were Luminal B type,39 cases were HER-2 overexpression type and 29 cases were triple-negative type.The difference of marginal burr signs of different molecular types was statistically significant(χ2=67.032,P<0.001).The expression rate of burrs was higher in the Luminal A type and Luminal B type of breast cancer.There were significant differences among different molecular types(χ2=14.849,P=0.002),and the expression rate of lobular signs was higher in Luminal B type and triple-negative type.The marginal burr signs were correlated with the positive expression rates of ER and PR.The marginal lobulation signs were correlated with the positive expression rates of ER and HER-2.There was a significant relationship between the marginal burr signs of breast cancer and the distribution trend of ER and PR positive line expression from weak to strong.There was a significant relationship between the marginal lobulation of breast cancer and the weak to strong distribution trend of ER positive expression.Conclusion The mammogram marginal burr signs were directly related to Luminal A and Luminal B molecular typing,while the non-burr signs mostly appeared in triple-negative breast cancer.Lobular signs can be used to judge Luminal B type an

关 键 词：乳腺癌 乳腺X线摄影术 边缘征象 生物学因子 分子分型 

分 类 号：R737.9[医药卫生—肿瘤]