丁苯酞联合银杏叶滴丸治疗缺血性脑卒中后认知功能障碍的效果研究  

Study on the effect of butylphthalide combined with ginkgo leaf dripping pills in the treatment of cognitive dysfunction after ischemic stroke

作　　者：李睿钧 黎翠芬 黄红芳 张子曼 叶金铃 叶锦雄 韩织优 LI Rui-jun;LI Cui-fen;HUANG Hong-fang(Department of Pharmacy,Guangzhou Dongsheng Hospital,Foshan 510700,China)

机构地区：[1]广州市东升医院药学部,510700 [2]广州市东升医院康复医学科,510700 [3]佛山市第五人民医院药学部,528211

出　　处：《中国现代药物应用》2022年第21期71-73,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探究丁苯酞联合银杏叶滴丸治疗缺血性脑卒中后认知功能障碍的效果。方法80例缺血性脑卒中后认知功能障碍患者,随机分为观察组与对照组,各40例。对照组接受丁苯酞治疗,观察组接受丁苯酞联合银杏叶滴丸治疗。比较两组治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、蒙特利尔认知评估量表(MoCA)评分、脑血流灌注指标[脑血容量(CBV)、脑血流量(CBF)、平均通过时间(MTT)]。结果治疗后,观察组NIHSS评分(3.23±1.18)分低于对照组的(7.11±1.49)分,MoCA评分(24.34±0.58)分高于对照组的(22.47±0.62)分,差异有统计学意义(P<0.05)。治疗后,观察组MTT(1.08±0.07)s短于对照组的(1.29±0.12)s,CBV(1.47±0.13)×10^(-2) ml/g大于对照组的(1.24±0.12)×10^(-2) ml/g,CBF(0.98±0.15)×10^(-2) ml/(g·min)快于对照组的(0.72±0.13)×10^(-2) ml/(g·min),差异有统计学意义(P<0.05)。结论予以缺血性脑卒中后认知功能障碍患者丁苯酞联合银杏叶滴丸治疗效果显著,可促进患者认知功能恢复,改善患者神经缺损及脑组织血流灌注情况,值得临床借鉴。Objective To investigate the effect of butylphthalide combined with ginkgo leaf dripping pills in the treatment of cognitive dysfunction after ischemic stroke.Methods A total of 80 patients with cognitive dysfunction after ischemic stroke were randomly divided into an observation group and a control group,with 40 cases in each group.The control group was treated with butylphthalide,and the observation group was treated with butylphthalide combined with ginkgo leaf dropping pills.The National Institutes of Health Stroke Scale(NIHSS)score,Montreal Cognitive Assessment(MoCA)score,and cerebral blood perfusion indexes[cerebral blood volume(CBV),cerebral blood flow(CBF),mean transit time(MTT)].Results After treatment,the NIHSS score(3.23±1.18)points of the observation group was lower than(7.11±1.49)points of the control group;the MoCA score(24.34±0.58)points of the observation group was higher than(22.47±0.62)points of the control group;the differences were all statistically significant(P<0.05).After treatment,the MTT(1.08±0.07)s of the observation group was shorter than(1.29±0.12)s of the control group;the CBV(1.47±0.13)×10^(-2) ml/g of the observation group was greater than(1.24±0.12)×10^(-2) ml/g of the control group;the CBF(0.98±0.15)×10^(-2) ml/(g·min)of the observation group was faster than(0.72±0.13)×10^(-2) ml/(g·min)of the control group;the differences were all statistically significant(P<0.05).Conclusion Butylphthalide combined with ginkgo leaf dripping pills has significant effect on patients with cognitive dysfunction after ischemic stroke,and can promote the recovery of cognitive function,improve the neurological deficit and cerebral blood perfusion,which is worthy of clinical reference.

关 键 词：认知功能障碍 银杏叶滴丸 缺血性脑卒中 丁苯酞 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]