低频聚焦超声对阿尔茨海默病治疗作用的研究进展  

Progress of Low-frequency focused ultrasound in treatment of Alzheimer's disease

作　　者：燕雨蝶 张震[1] Yudie YAN;Zhen ZHANG(Department of ultrasound,First Affiliated Hospital of China Medical University,Shenyang City,Liaoning Province,People’s Republic of China Shenyang 110002)

机构地区：[1]中国医科大学附属第一医院超声科,沈阳110002

出　　处：《阿尔茨海默病及相关病杂志》2022年第4期324-327,共4页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：国家自然科学基金(81971639)。

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是慢性中枢神经系统变性疾病之一,血脑屏障的存在阻碍了许多药物的应用,导致目前仍没有有效的治疗方法。低频聚焦超声(Low-frequency focused ultrasound,LFUS)是一种十分安全的新兴治疗方法,可以发挥靶向递送药物、开放血脑屏障、促进脑部血液循环等作用。本文就低频聚焦超声目前在阿尔茨海默病治疗中的研究进展做综述。Alzheimer's disease(AD)is one of the chronic degenerative diseases of the central nervous system.The existence of blood-brain barrier hinders the application of drugs,resulting in no effective treatment of Alzheimer's disease.Low-frequency focused ultrasound(LFUS)is a safe and new treatment method,which can play a role in targeted delivery of drugs,opening blood-brain barrier and promoting cerebral blood circulation.This review will summarize the research progress of low-frequency focused ultrasound in the treatment of Alzheimer's disease.

关 键 词：阿尔茨海默病 聚焦超声 微泡 磁共振 血脑屏障 

分 类 号：R741[医药卫生—神经病学与精神病学]