肿瘤电场治疗在神经胶质瘤治疗中的研究进展  

Research progress of tumor treating fields in the treatment of glioma

作　　者：李琳[1] 刘超[1] 邵将 郭岩松 温稀超 曾昭穆 郑克彬[1] LI Lin;LIU Chao;SHAO Jiang;GUO Yansong;WEN Xichao;ZENG Zhaomu;ZHENG Kebin(Department of Neurosurgery,the Affiliated Hospital of Hebei University,Baoding 071000,China)

机构地区：[1]河北大学附属医院神经外科,河北保定071000 [2]河北大学附属医院中心实验室,河北保定071000

出　　处：《实用医学杂志》2022年第22期2763-2767,共5页The Journal of Practical Medicine

基　　金：河北省自然科学基金(编号:H2016201238);2019政府资助临床医学优秀人才培养项目(编号:361007);河北大学医学学科重点项目(编号:2020A11);河北大学附属医院2019年度院内基金项目(编号:2019Z003)。

摘　　要：肿瘤电场治疗(tumor treating fields,TTFields)通过低强度、中频率的交变电场对肿瘤部位进行非侵入性局部物理性抗肿瘤治疗。近年来,研究发现TTFields具有抑制细胞增殖、诱导细胞凋亡和增强免疫反应、抑制细胞转移、增加细胞膜通透性以及破坏血脑屏障的作用。神经胶质瘤具有浸润性生长、高度恶性、复发率高的特点,目前综合治疗效果欠佳。研究表明,通过TTFields与放化疗以及分子靶向药物联合应用,可以改善神经胶质瘤患者的预后。本文就TTFields在神经胶质瘤治疗中的抗肿瘤机制、临床治疗中的优势及副作用、适用人群等方面作一综述,同时也提出了TTFields在神经胶质瘤治疗研究中的新方向。Tumor treating fields(TTFields)are non-invasive local physical antitumor treatment of tumor sites by alternating electric fields of low intensity and medium frequency.In recent years,TTFields have been found to inhibit cell proliferation,induce apoptosis,enhance immune response,inhibit cell metastasis,increase cell membrane permeability,and destroy the blood-brain barrier.Glioma is characterized by invasive growth,high malignancy,and high recurrence rate.Studies have shown that TTFields,in combination with chemoradiotherapy and molecularly targeted agents,can improve the prognosis of patients with glioma.In this paper,the antitumor mechanism,clinical advantages,and side effects of TTFields in glioma treatment,and applicable population of TTFields are reviewed.Meanwhile,a new direction of TTFields in glioma research is proposed.

关 键 词：肿瘤电场治疗 神经胶质瘤 分子机制 治疗 预后 

分 类 号：R739.41[医药卫生—肿瘤]