后交通动脉瘤破裂风险因素分析与评估  

Risk Factors Analysis and Assessment of Ruptured Posterior Communicating Artery Aneurysm

作　　者：丁煜昊 王剑刃[1] 谢涛 林荔青[1] 林泽西 朱巍巍[2] 傅西安[1] 蒲军[3] DING Yuhao;WANG Jianren;XIE Tao;LIN Liqing;LIN Zexi;ZHU Weiwei;FU Xi’an;PU Jun(Dept.of Neurosurgery,The Affiliated Suzhou Hospital of Nanjing Medical University/Suzhou Municipal Hospital/Gusu School,Nanjing Medical University,Suzhou Jiangsu 215008;Dept.of Neurosurgery,The 1st Affiliated Hospital of Soochow University,Suzhou Jiangsu 215031,China;Dept.of Neurosurgery,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650033)

机构地区：[1]南京医科大学姑苏学院/苏州市立医院/南京医科大学附属苏州医院神经外科,江苏苏州215008 [2]苏州大学附属第一医院神经外科,江苏苏州215031 [3]昆明医科大学第二附属医院神经外科,云南昆明650033

出　　处：《昆明医科大学学报》2022年第12期47-52,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(82160512);苏州市临床重点病种诊疗技术专项基金资助项目(LCZX 201913);苏州大学技术开发横向资助课题基金资助项目(P112205519)。

摘　　要：目的分析后交通动脉瘤破裂的风险因素,筛选形态学和血流动力学预测指标。方法选取2019年3月至2021年12月南京医科大学附属苏州医院、苏州大学附属第一医院收治的后交通动脉瘤患者资料共78例。其中破裂动脉瘤49例作为观察组,未破裂动脉瘤29例作为对照组。比较性别,年龄,吸烟史,高血压病史,糖尿病史、动脉瘤大小、高宽比(aspect ratio,AR)、大小比率(size ratio,SR)、波动指数(undulation index,UI)、非球形指数(nonsphericity index,NSI)、椭形指数(ellipticity Index,EI)、壁面切应力(wall shear stress,WSS)、切应力梯度(wall shear stress gradient,WSSG)、振荡剪切指数(oscillatory shear index,OSI)等参数。结果2组临床因素中年龄、性别、吸烟史、高血压及糖尿病史,差异均无统计学意义(P>0.05);形态学分析结果:最大径、SR、UI、NSI 2组比较,差异有统计学意义(P<0.05),AR、NSI、EI差异无统计学意义(P>0.05);形态学分析结果:WSS(Pa)2组比较,差异有统计学意义(P<0.05);WSSG(Pa/mm)、OSI差异无统计学意义(P>0.05)。结论动脉瘤的大小、不规则的瘤壁形态与动脉瘤破裂有密切联系;低WSS可能是后交通动脉瘤破裂的独立风险因素。Objective To investigate the risk factors of rupture of posterior communicating aneurysm and screen the morphologic and hemodynamic predictors.Methods A total of 78 patients with posterior communicating aneurysm diagnosed in the neurosurgery department of the Affiliated Suzhou Hospital of Nanjing Medical University,the First Affiliated Hospital of Soochow University from March 2019 to December 2021 with complete clinical data and meeting the inclusion criteria were retrospectively analyzed.49 cases of ruptured aneurysm were in the observation group,and 29 cases of unruptured aneurysm were in the control group.Clinical data included sex,age,smoking history,history of hypertension,history of diabetes.Morphological data included aneurysm size,aspect ratio(AR),size ratio(SR),undulation index(UI),nonsphericity index(NSI),elliptic Index(EI).The hemodynamic parameters include Wall Shear Stress(WSS),Wall Shear Stress Gradient(WSSG)and Oscillatory Shear index(OSI).Results There was no statistically significant difference between the two groups(P>0.05)in age,sex,history of smoking,hypertension and diatetes.Morphological analysis showed that there were significant differences in maximum diameter,SR,UI and NSI between two groups(P<0.05).There were no significant differences in AR,NSI and EI(P>0.05).Morphological analysis showed that WSS(Pa)was significantly different between the two groups(P<0.05),WSSG(Pa/mm)and OSI had no significant difference(P>0.05).Conclusion Aneurysm size and irregular wall shape are closely related to aneurysm rupture.Low WSS may be an independent risk factor for posterior communicating aneurysm rupture.

关 键 词：颅内动脉瘤 危险因素 流行病学 血流动力学 

分 类 号：R743[医药卫生—神经病学与精神病学]