Alkaline phosphatase flare with hyperostosis of bone metastases in lung adenocarcinoma treated with gefitinib  

作　　者：Hiroto Kaneko Kazuho Shimura Yosuke Matsumoto Mihoko Yoshida Masafumi Taniwaki Junya Kuroda 

机构地区：[1]Department of Hematology,Aiseikai Yamashina Hospital,19-4 Shichouno-cho,Yamashina-ku,Kyoto 607-8086,Japan [2]Department of Hematology,Kyoto Prefectural University of Medicine,465 Kajii-cho,Kawaramachi Hirokoji,Kamigyou-ku,Kyoto 602-8566,Japan

出　　处：《Journal of Cancer Metastasis and Treatment》2017年第1期34-37,共4页癌症转移与治疗（英文版）

摘　　要：Alkaline phosphatase(ALP)flare has been reported to occur during cancer treatment as a favorable event,particularly in the presence of bone metastasis.There have been only a few reports in lung cancer and associated radiographic findings have seldom been described.The authors observed ALP flare in a female patient with lung adenocarcinoma soon after the initiation of gefitinib.Moreover,on computed tomography,metastatic lesions of the rib and thoracic spine showed marked hyperostosis,with sizes larger than the original bone structure,suggesting efficacy of gefitinib.The significance of such hyperostosis should be elucidated.

关 键 词：Alkaline phosphatase bone metastasis HYPEROSTOSIS GEFITINIB 

分 类 号：R73[医药卫生—肿瘤]