Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy:revising an option for peritoneal carcinomatosis  

作　　者：Filipa Macedo Katia Ladeira Adhemar Longatto-Filho Sandra F.Martins 

机构地区：[1]Portuguese Oncology Institute-Coimbra,Coimbra 3000-075,Portugal [2]Portuguese Oncology Institute-Lisbon,Lisbon 1099-023,Portugal [3]Life and Health Science Research Institute,School of Health Sciences,University of Minho,Braga 4710-057,Portugal [4]ICVS/3B's-PT Government Associate Laboratory,Braga/Guimaraes,Braga 4710-057,Portugal [5]Molecular Oncology Research Center,Barretos Cancer Hospital,Barretos,Sao Paulo 14784-400,Brazil [6]Laboratory of Medical Investigation 14,Faculty of Medicine,University of Sao Paulo,Sao Paulo 01246-903,Brazil [7]Surgery Department,Coloproctology Unit,Braga Hospital,Braga 4710-243,Portugal

出　　处：《Journal of Cancer Metastasis and Treatment》2018年第1期104-109,共6页癌症转移与治疗（英文版）

摘　　要：Aim:Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to dista nt orga n metastasis.The systemic chemotherapy has a mini mal effect in peritoneal metastasis so new types of treatment have emerged.The authors revised the main studies done in pressurized in traperit on eal aerosol chemotherapy(PIPAC)and prese nted the main con clusi ons.Methods:A PubMed search was con ducted focus ing on PIPAC in gastric can cer.The MeSH database was searched with the terms:"Gastric can cer[MeSH]and in traperit on eal aerosol chemotherapy".Results:Seve n studies were an alyzed.All the studies performed the tech nique with aerosol of doxorubic in and cisplat in.All cases were well tolerated,with minor adverse effects.Patients presented resolution of their abdominal symptoms and regression of macroscopic carcinomatosis.Cytoreductive surgery or hypertermic intraperitoneal chemotherapy could be performed in some patients with good response to PIPAC.The peritonitis caused by the chemotherapy was well tolerated.Conclusion:PIPAC can induce remission in end-stage and resistant disease with acceptable side effects,good safety levels for patients and health professionals,and quality of life improvement.

关 键 词：Pressurized intraperitoneal aerosol chemotherapy gastric cancer peritoneal carcinomatosis 

分 类 号：R73[医药卫生—肿瘤]