The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent:a preliminary report  

作　　者：Chrissa Sioka Thomas Exarchopoulos Vlasis Skloupiotis Vaios Papathanassiou Vasileios Ragos Maria Argyropoulou Anna Gousia Periklis Tsekeris Georgios Exarchakos Dimitrios Assimakopoulos Andreas Fotopoulos 

机构地区：[1]Department of Nuclear Medicine,University of Ioannina School of Medicine,University Campus,Ioannina 45110,Greece [2]Department of Radiotherapy,University of Ioannina School of Medicine,University Campus,Ioannina 45110,Greece [3]Department of Ear Nose and Throat,University of Ioannina School of Medicine,University Campus,Ioannina 45110,Greece [4]Department of Maxillofacial Surgery,University of Ioannina School of Medicine,University Campus,Ioannina 45110,Greece [5]Department of Radiology,University of Ioannina School of Medicine,University Campus,Ioannina 45110,Greece [6]Department of Pathology,University of Ioannina School of Medicine,University Campus,Ioannina 45110,Greece

出　　处：《Journal of Cancer Metastasis and Treatment》2016年第1期133-138,共6页癌症转移与治疗（英文版）

摘　　要：Aim:To evaluate the diagnostic value of technetium Tc99m-tetrofosmin(^(99m)Tc-TF)in primary cancers of the head and neck.Methods:Single photon emission computer tomography with planar imaging of the neck for primary site evaluation and whole body scanning for assessment of metastases in 12 patients with newly diagnosed head and neck cancer.Tumor-to-background index(T/Bg)was derived in patients with positive findings(tumor or lymph nodes).Results:The tomographic images showed increased tracer uptake in pathological sites(primary tumor or lymph node)in 9 patients(overall sensitivity 75%).Primary tumor was visualised in 7 patients(sensitivity 58%)and infiltrated lymph nodes in 4 out 7 patients(sensitivity 57%).Mean values for T/Bg index were 5.44±1.28 for primary tumor and 4.25±1.67 for lymph nodes.Mean values for T/Bg index were 4.5±0.71 for patients with in situ and grade I carcinoma and 6.68±0.36 for patients with tumor grade II and III(P=0.034,Mann-Whitney U test).Conclusion:The present study demonstrates that ^(99m)Tc-TF is a valuable radiotracer for head and neck cancer imaging.To determine the potential role of this imaging protocol in clinical practice will require a larger sample size.

关 键 词：Head and neck cancer radionuclide imaging single photon emission computer tomography ^(99m)Technetium-tetrofosmin 

分 类 号：R73[医药卫生—肿瘤]