宫颈癌患者外周血BAFF、PD-L1、IL-10表达水平及其与预后的关系  

Expression of BAFF,PD-L1 and IL-10 in peripheral blood of patients with cervical carcinoma and their relationship with prognosis

作　　者：周明 许昭 徐妮妮 ZHOU Ming;XU Zhao;XU Nini(No.3 Gynecological Tumor Ward,Shaanxi Provincial Cancer Hospital,Xi'an 710061;Gynecology and Obstetrics Department,the Second Affiliated Hospital of Air Force Military Medical University,Xi'an 710038,China)

机构地区：[1]陕西省肿瘤医院妇瘤三病区,陕西西安710061 [2]空军军医大学第二附属医院妇产科,陕西西安710038

出　　处：《临床医学研究与实践》2022年第36期39-42,47,共5页Clinical Research and Practice

基　　金：陕西省社会发展科技攻关项目(No.2020A039)。

摘　　要：目的探究B淋巴细胞活化因子(BAFF)、程序性死亡配体-1(PD-L1)、白细胞介素-10(IL-10)在宫颈癌(CCA)患者外周血中的表达水平及其与预后的关系。方法选取2018年6月至2019年6月我院收治的98例CCA患者作为研究对象,根据随访3年内CCA有无进展将患者分为无进展组(n=79)与有进展组(n=19)。比较两组外周血BAFF、PD-L1、IL-10表达情况,并分析其与CCA患者临床病理特征及预后的关系。结果有进展组低分化和有淋巴结转移的患者占比均高于无进展组(P<0.05)。有进展组的外周血BAFF阳性表达率低于无进展组,PD-L1阳性表达率及IL-10表达高于无进展组(P<0.05)。相较于中、高分化、无淋巴结转移的CCA患者,低分化、有淋巴结转移的CCA患者的外周血BAFF阳性表达率降低,PD-L1阳性表达率及IL-10表达均升高(P<0.05)。Cox回归分析显示,低分化、有淋巴结转移、BAFF低表达、PD-L1高表达、IL-10高表达是影响CCA患者预后的危险因素(P<0.05)。受试者工作特征(ROC)曲线显示,外周血BAFF、PD-L1及IL-10预测CCA患者预后的曲线下面积(AUC)分别为0.823、0.803、0.787,三者联合检测对CCA患者预后的预测价值最高,AUC为0.837,灵敏度为94.74%,特异度为65.82%。结论外周血BAFF、PD-L1、IL-10异常表达是影响CCA患者预后的危险因素,早期进行三者联合检测对患者预后有较高的预测价值。Objective To investigate the expression of B cell activation factor(BAFF),programmed death ligand 1(PD-L1)and interleukin-10(IL-10)in peripheral blood of patients with cervical carcinoma(CCA)and their relationship with prognosis.Methods A total of 98 patients with CCA admitted in our hospital from June 2018 to June 2019 were selected as the research objects,and the patients were divided into non-progressive group(n=79)and progressive group(n=19)according to whether CCA had progressed within 3 years of follow-up.The expression of peripheral blood BAFF,PD-L1 and IL-10 were compared between the two groups,and their relationship with clinicopathological features and prognosis of CCA patients were analyzed.Results The proportions of patients with poor differentiation and lymph node metastasis in the progressive group were higher than those in the non-progressive group(P<0.05).The positive expression rate of peripheral blood BAFF in the progressive group was lower than that in the non-progressive group,and the positive expression rate of PD-L1 and the expression of IL-10 were higher than those in the non-progressive group(P<0.05).Compared with CCA patients with moderate to high differentiation and non-lymph node metastasis,the positive expression rate of peripheral blood BAFF of CCA patients with low differentiation and lymph node metastasis decreased,while the positive expression rate of PD-L1 and the expression of IL-10 increased(P<0.05).Cox regression analysis showed that poor differentiation,lymph node metastasis,low expression of BAFF,high expression of PD-L1 and high expression of IL-10 were risk factors affecting the prognosis of CCA patients(P<0.05).The receiver operating characteristic(ROC)curve showed that the area under curve(AUC)of peripheral blood BAFF,PD-L1 and IL-10 in predicting the prognosis of CCA patients was 0.823,0.803 and 0.787,respectively;the combined detection of the three had the highest predictive value for the prognosis of CCA patients,with AUC of 0.837,sensitivity of 94.74%and specificity o

关 键 词：宫颈癌 B淋巴细胞活化因子 程序性死亡配体-1 白细胞介素-10 

分 类 号：R737.33[医药卫生—肿瘤]