腹腔镜辅助远端胃癌D_(2)根治术治疗无浆膜层侵犯的进展期胃癌的效果及对炎症指标的影响  

Effect of laparoscopic-assisted distal D_(2) radical gastrectomy on advanced gastric cancer without serosal invasion and its influence on inflammatory indexes

作　　者：尹金祥 连凌云 马任远[1] 邢国强 YIN Jinxiang;LIAN Lingyun;MA Renyuan;XING Guoqiang(the First Ward of General Surgery Department,Yulin No.2 Hospital,Yulin 719000;Oncology Department,the First Hospitalin Weinan,Weinan 714000,China)

机构地区：[1]榆林市第二医院普通外科一病区,陕西榆林719000 [2]渭南市第一医院肿瘤科,陕西渭南714000

出　　处：《临床医学研究与实践》2022年第36期102-105,110,共5页Clinical Research and Practice

摘　　要：目的分析腹腔镜辅助远端胃癌D_(2)根治术治疗无浆膜层侵犯的进展期胃癌的效果。方法选取2016年1月2日至2020年1月2日收治的60例无浆膜层侵犯的进展期胃癌患者为研究对象,采取抽签法将其分为观察组(30例,腹腔镜辅助远端胃癌D_(2)根治术治疗)和对照组(30例,常规手术治疗)。比较两组的术后并发症发生情况、手术指标、术中并发症发生情况、临床疗效及炎症指标。结果观察组的术后并发症总发生率低于对照组,差异具有统计学意义(P<0.05)。观察组的排气时间、切口长度、住院时间短于对照组,术中出血量少于对照组,差异具有统计学意义(P<0.05);两组的手术时间、淋巴结清扫数比较,差异无统计学意义(P>0.05)。两组的术中并发症总发生率比较,差异无统计学意义(P>0.05)。观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。手术前,两组的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、干扰素-γ(IFN-γ)、转化生长因子-β(TGF-β)水平比较,差异无统计学意义(P>0.05);手术后,两组的TNF-α、IL-6水平高于手术前,IFN-γ、TGF-β水平低于手术前,差异具有统计学意义(P<0.05);手术后,观察组的TNF-α、IL-6水平低于对照组,差异具有统计学意义(P<0.05);手术后,两组的IFN-γ、TGF-β水平比较,差异无统计学意义(P>0.05)。结论腹腔镜辅助远端胃癌D_(2)根治术治疗无浆膜层侵犯的进展期胃癌的效果显著,可降低术后并发症发生率,且炎症应激反应较小,值得临床应用。Objective To analyze the effect of laparoscopic-assisted distal D_(2)radical gastrectomy on advanced gastric cancer without serosal invasion.Methods From January 2,2016 to January 2,2020,60 patients with advanced gastric cancer without serosal invasion were selected as the research objects,and the patients were divided into observation group(30 cases,laparoscopic-assisted distal D_(2)radical gastrectomy treatment)and control group(30 cases,conventional surgical treatment)by drawing lots.The postoperative complications,surgical indicators,intraoperative complications,clinical efficay and inflammatory indicators were compared between the two groups.Results The total incidence of postoperative complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The exhaust time,incision length and hospitalization time in the observation group were shorter than those in the control group,the intraoperative blood loss was less than that in the control group,and the differences were statistically significant(P<0.05);there were no significant differences in the operation time and the number of lymph node dissection between the two groups(P>0.05).There was no significant difference in the total incidence of intraoperative complications between the two groups(P>0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before operation,there were no significant differences in the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interferon-γ(IFN-γ)and transforming growth factor-β(TGF-β)between the two groups(P>0.05);after operation,the levels of TNF-αand IL-6 in the two groups were higher than those before operation,and the levels of IFN-γand TGF-βwere lower than those before operation,the differences were statistically significant(P<0.05);after operation,the levels of TNF-αand IL-6 in the observation group were lower than thos

关 键 词：腹腔镜 远端胃癌D_(2)根治术 进展期胃癌 

分 类 号：R735.2[医药卫生—肿瘤]