替罗非班注射液治疗超溶栓时间窗脑梗死OCSP各型预后的疗效观察  

Therapeutic effect of tirofiban injection on prognosis of various OCSP classifications of cerebral infarction beyond the thrombolytic time window

作　　者：郑宾 周红[2] 黄煜琛 郑永洁 Zheng Bin;Zhou Hong;Huang Yuchen;Zheng Yongjie(Department of Neurology,Chaoyang District Dafeng Hospital,Shantou 515154,Guangdong;Department of Neurology,Guangxi Zhuang Autonomous Region Jiangbin Hospital,Nanning 530021,Guangxi,China)

机构地区：[1]广东省汕头市潮阳区大峰医院,神经内科,广东汕头515154 [2]广西壮族自治区江滨医院,神经内科,广西南宁530021

出　　处：《广州医科大学学报》2022年第5期58-61,共4页Academic Journal of Guangzhou Medical University

摘　　要：目的:探讨替罗非班注射液治疗超溶栓时间窗脑梗死牛津郡社区卒中计划(OCSP)分型各型患者预后的疗效。方法:选择我院2019年1月至2021年2月间收治的132例超溶栓时间窗脑梗死患者。其中,腔隙性脑梗塞(LACI)32例、完全前循环梗塞(TACI)30例、部分前循环梗塞(PACI)35例、后循环梗塞(POCI)35例。所有患者参照脑梗死常规治疗基础上均予以替罗非班注射液治疗,比较不同OCSP分型患者治疗前后神经功能缺损评分(NIHSS)变化及预后疗效。结果:OCSP各分型患者治疗后相较于治疗前NIHSS评分均显著降低(P<0.05);TACI型治疗后NIHSS评分降低差值大于LACI型、POCI型、PACI型(P<0.05),POCI型、PACI型治疗后NIHSS评分降低差值大于LACI型(P<0.05);LACI型预后良好率(100.00%)高于POCI型、PACI型、TACI型,POCI型与PACI型预后良好率(80.00%、77.14%)高于TACI型(50.00%)(P<0.05)。结论:替罗非班注射液对超溶栓时间窗脑梗死OCSP各型患者均具有良好的疗效,相较而言,LACI型疗效最优,TACI型疗效最差。Objective:To investigate the therapeutic effect of tirofiban injection on the prognosis of cerebral infarction according to Oxfordshire Community Stroke Program(OCSP)classifications beyond the thrombolytic time window.Methods:A total of 132 patients with cerebral infarction treated in our hospital between January 2019 and February 2021 were included.Among them,there were 32 cases of lacunar infarction(LACI),30 of total anterior circulation infarction(TACI),35 of partial anterior circulation infarction(PACI),and 35 of posterior circulation infarction(POCI).All patients received tirofiban injection in addition to conventional treatment for cerebral infarction.The changes in neurological deficit(NIHSS score)before vs after treatment and the prognosis were compared among patients with different OCSP classifications.Results:Patients with any OCSP classification experienced significantly lower NIHSS score after treatment compared with baseline(P<0.05).The reduction in NIHSS scores after treatment was greater in TACI than that in LACI,POCI and PACI(P<0.05);the reduction in NIHSS scores after treatment was greater in POCI and PACI than that in LACI(P<0.05).The proportion of patients with favorable prognosis was higher in LACI(100%)than that in POCI,PACI or TACI.The proportions of patients with favorable prognosis were higher in POCI(80.00%)and PACI(77.14%)than that in TACI(50.00%)(P<0.05).Conclusion:Tirofiban injection offers good therapeutic effect on cerebral infarction of different OCSP classifications beyond the thrombolytic time window.In comparison,the efficacy seems to be best in LACI and worst in TACI.

关 键 词：替罗非班 脑梗死 超溶栓时间窗 疗效 

分 类 号：R742[医药卫生—神经病学与精神病学]