联合井穴刺络放血疗法对风火上扰证癫痫患者脑电图分级、神经递质、氧化—抗氧化系统的影响  

Effects of Combined Jing-point Pricking and Bloodletting Therapy on EEG Classification,Neurotransmitters,and Oxidative-antioxidant Systems in Epilepsy Patients with Syndrome of Upward Disturbance of Wind-Fire

作　　者：邢鑫[1] 石会[1] XING Xin;SHI Hui(Department of Neurology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)

机构地区：[1]石家庄市中医院神经内科,石家庄050000

出　　处：《临床误诊误治》2022年第11期94-97,107,共5页Clinical Misdiagnosis & Mistherapy

基　　金：河北省中医药管理局项目(2022170)。

摘　　要：目的探讨井穴刺络放血疗法联合丙戊酸钠片对风火上扰证癫痫患者脑电图分级、神经递质、氧化-抗氧化系统的影响。方法回顾性分析2020年3月—2022年3月收治的癫痫135例的临床资料,根据治疗方案分为观察组68例和对照组67例,对照组给予丙戊酸钠片治疗,观察组在对照组基础上给予井穴刺络放血疗法。统计2组治疗效果、不良反应及治疗前后脑电图分级、神经递质[多巴胺(DA)、5-羟色胺(5-HT)、谷氨酸(Glu)]、氧化-抗氧化指标[丙二醛(MDA)、超氧化物歧化酶(SOD)、髓过氧化物(MPO)]水平。结果观察组总有效率高于对照组(P<0.05)。治疗后观察组脑电图正常患者所占比例较对照组高,中度异常患者所占比例较对照组低(P<0.05)。治疗后,观察组DA、5-HT、SOD水平高于对照组,Glu、MPO、MDA水平低于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论井穴刺络放血疗法联合丙戊酸钠片可改善风火上扰证癫痫患者脑电图分级,调节神经递质水平,平衡氧化-抗氧化系统,治疗效果较好,且安全性高。Objective To investigate the effects of Jing-point pricking and bloodletting therapy combined with Sodium Valproate Tablets on EEG classification,neurotransmitter and oxidation-antioxidant system in epilepsy patients with syndrome of upward disturbance of wind-fire.Methods The clinical data of 135 patients with epilepsy admitted from March 2020 to March 2022 were retrospectively analyzed.According to the treatment plan,the patients were divided into observation group(n=68)and control group(n=67).The control group was treated with Sodium Valproate Tablets,and the observation group was treated with Jing-point pricking and bloodletting therapy on the basis of the control group.The therapeutic effect,adverse reactions,EEG classification,neurotransmitters[dopamine(DA),5-hydroxytryptamine(5-HT),glutamic acid(Glu)],oxido-antioxidant indexes[malonaldehyde(MDA),superoxide dismutase(SOD),myeloperoxidase(MPO)]before and after treatment were calculated in the 2 groups.Results The total effective rate of the observation group was higher than that of control group(P<0.05).After treatment,the proportion of patients with normal EEG in the observation group was higher than that in the control group,and the proportion of patients with moderately abnormal EEG was lower than that in the control group(P<0.05).After treatment,the levels of DA,5-HT and SOD in the observation group were higher than those in the control group,while the levels of Glu,MPO and MDA in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Jing-point pricking and bloodletting therapy combined with Sodium Valproate Tablets can improve the EEG classification,regulate the level of neurotransmitters,and balance the oxidation-antioxidant system in epilepsy patients with syndrome of upward disturbance of wind-fire,which has favorable therapeutic effect and good safety.

关 键 词：癫痫 风火上扰型 井穴刺络放血疗法 脑电图 多巴胺 5-羟色胺 丙二醛 超氧化物歧化酶 

分 类 号：R742.1[医药卫生—神经病学与精神病学]