穿心莲内酯衍生物的合成及活性研究进展  

Research progress on synthesis and activity of andrographolide derivatives

作　　者：刘天福 杜枭年 张义福 张建 LIU Tian-fu;DU Xiao-nian;ZHANG Yi-fu;ZHANG Jian(School of Pharmacy,Gansu University of Chinese Medicine;Key Laboratory of Chemistry and Quality for TCM of the College of Gansu Province,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学药学院 [2]甘肃省高校中(藏)药化学与质量研究省级重点实验室,兰州730000

出　　处：《天然产物研究与开发》2022年第12期2142-2161,共20页Natural Product Research and Development

基　　金：国家自然科学基金(21562001);引进人才科研启动基金(998602140401)。

摘　　要：穿心莲内酯为我国传统中药穿心莲的主要活性成分之一。近年来,许多研究小组以穿心莲内酯为先导化合物,在抗肿瘤、抗炎、抗菌和抗病毒药物的开发方面进行了大量的实验研究。本文对近年来穿心莲内酯衍生物的合成及活性研究进展进行了系统的总结,并揭示其构效关系,以期为进一步基于穿心莲内酯开发新药提供一定的指导。In recent years,many research groups have carried out a large number of experimental studies based on andrographolide as a lead compound in the development of antitumor,anti-inflammatory,antibacterial and antiviral drugs.In order to provide some guidance for the further research and development of new drugs based on andrographolide,this paper systematically summarizes the research progress in the synthesis and activity of andrographolide derivatives in recent years and reveals their structure-activity relationship.

关 键 词：穿心莲内酯 衍生物 合成 活性 

分 类 号：R914.2[医药卫生—药物化学]