小牛血清去蛋白注射液联合马来酸桂哌齐特注射液治疗老年血管性痴呆患者的效果  

Effects of Deproteinised calf serum injection combined with Cinepazide maleate injection in treatment of elderly patients with vascular dementia

作　　者：王红 WANG Hong(Department of Neurology of Jiamusi Orthopedic Hospital,Jiamusi 154002 Heilongjiang,China)

机构地区：[1]佳木斯骨科医院神经内科,黑龙江佳木斯154002

出　　处：《中国民康医学》2022年第22期30-32,39,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察小牛血清去蛋白注射液联合马来酸桂哌齐特注射液治疗老年血管性痴呆患者的效果。方法:选取2019年5月至2021年5月该院收治的96例老年血管性痴呆患者进行前瞻性研究,按照随机数字表法分为研究组与对照组各48例。对照组采用马来酸桂哌齐特注射液治疗,研究组在对照组基础上联合小牛血清去蛋白注射液治疗。比较两组临床疗效,治疗前后日常生活活动能力(Barthel指数)评分、认知能力[简易精神状态检查表(MMSE)]评分及γ干扰素(IFN-γ)、同型半胱氨酸(Hcy)和阿尔茨海默病相关神经丝蛋白(AD7c-NTP)水平,以及不良反应发生率。结果:研究组治疗总有效率为95.83%,高于对照组的83.33%,差异有统计学意义(P<0.05);治疗后,两组Barthel指数评分和MMSE评分均高于治疗前,且研究组高于对照组,差异有统计意义(P<0.05);两组IFN-γ、Hcy、AD7c-NTP水平均低于治疗前,且研究组低于对照组,差异有统计意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小牛血清去蛋白注射液联合马来酸桂哌齐特注射液治疗老年血管性痴呆患者可提高治疗总有效率、Barthel指数评分和MMSE评分,降低IFN-γ、Hcy、AD7c-NTP水平,效果优于单纯马来酸桂哌齐特注射液治疗。Objective:To observe effects of Deproteinised calf serum injection combined with Cinepazide maleate injection in treatment of elderly patients with vascular dementia.Methods:96 elderly patients with vascular dementia admitted to the hospital from May 2019 to May 2021 were selected for the prospective study.According to the random number table method,they were divided into study group and control group,48 cases in each group.The control group was treated with Cinepazide maleate injection,while the study group was treated with Deproteinised calf serum injection on the basis of that of the control group.The clinical efficacy,the activities of daily living(Barthel index)score,the cognitive ability[Mini-mental state examination(MMSE)]score,the levels of interferon-γ(IFN-γ),homocysteine(Hcy)and Alzheimer’s disease-related neurofilament protein(AD7 c-NTP),and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 95.83%,which was higher than 83.33%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the Barthel index score and the MMSE score of the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of IFN-γ,Hcy and AD7 c-NTP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Deproteinised calf serum injection combined with Cinepazide maleate injection in the treatment of the elderly patients with vascular dementia can improve the total effective rate,the Barthel index score and the MMSE score,and reduce the levels of IFN-γ,Hcy and AD7c-NTP.Moreover,it is sup

关 键 词：小牛血清去蛋白注射液 马来酸桂哌齐特注射液 老年 血管性痴呆 MMSE评分 BARTHEL指数 不良反应 

分 类 号：R749[医药卫生—神经病学与精神病学]