卵巢癌组织HE4、STAT3表达及其经阴道多普勒血流频谱特征分析  

Analysis of the expressions of human sapiens epididymis specific protein 4 and signal transducer and activator of transcription 3 in ovarian cancer tissues of patients and the spectrum signature analysis of the blood flow of the ovarian cancer by transvaginal Doppler

作　　者：张莉 段庆红 ZHANG Li;DUAN Qinghong(School of Medical Imaging,Guizhou Medical University,550001;Guiyang Maternal and Child Health Care Hospital;Guizhou Cancer Hospital)

机构地区：[1]贵州医科大学医学影像学院,550001 [2]贵州省贵阳市妇幼保健院 [3]贵州省肿瘤医院

出　　处：《中国计划生育学杂志》2022年第12期2880-2883,共4页Chinese Journal of Family Planning

基　　金：贵州省科技合作计划项目[黔科合支撑(2021)一般451]。

摘　　要：目的:探讨卵巢癌组织中人附睾上皮分泌蛋白4(HE4)、信号转导和转录激活因子3(STAT3)表达水平及其经阴道彩色多普勒超声(TVCDS)血流参数特征。方法:收集2018年6月-2020年9月本院收治的卵巢癌患者65例为卵巢癌组,卵巢良性肿瘤患者61例为良性肿瘤组,免疫组化法检测手术切除组织中HE4、STAT3蛋白表达水平;TVCDS测定卵巢阻力指数(RI)、搏动指数(PI),分析卵巢癌组织不同HE4、STAT3表达水平者TVCDS血流参数RI、PI的差异。结果:卵巢癌组HE4(78.5%)、STAT3(67.7%)阳性表达率均高于良性肿瘤组(11.5%、19.7%),卵巢RI(0.46±0.15)、PI(0.85±0.28)均低于良性肿瘤组(1.03±0.34、2.17±0.72),卵巢癌组织HE4、STAT3阳性患者RI、PI均低于阴性患者(均P<0.05);卵巢癌组织HE4与STAT3表达水平呈正相关(P<0.05)。结论:卵巢癌组织HE4、STAT3表达异常升高,TVCDS血流参数RI、PI降低,HE4、STAT3与TVCDS血流参数联合检测有望成为鉴别卵巢癌指标。Objective:To investigate the expression levels of human sapiens epididymis specific protein 4(HE4)and signal transducer and activator of transcription3(STAT3)in ovarian cancer tissues of patients,and to study the blood flow parameter characteristic of ovarian cancer by transvaginal color Doppler ultrasound(TVCDS).Methods:From June 2018 to September 2020,65 patients with ovarian cancer were selected in study group,and 61 patients with benign ovarian tumors were selected in control group during the same period.The protein expression levels of HE4 and STAT3 in the resected ovarian cancer tissues after surgery were detected by immunohistochemistry.T VCDS was used to measure the resistance index(RI)and pulsation index(PI)of the blood flow of the ovarian cancer.The differences of blood flow parameters(RI and PI)values of the patients with different expression levels of HE4 and STAT3 in ovarian cancer tissues were analyzed.Results:The positive expression rates of HE4(78.5%)and STAT3(67.7%)in ovarian cancer tissues of the patients in the study group were significantly higher than those(11.5%and 19.7%)of the patients in the control group.The values of RI(0.46±0.15)and PI(0.85±0.28)of the blood flow of the ovarian cancer of the patients in the study group were significantly lower than those(1.03±0.34 and 2.17±0.72)of the patients in the control group.The RI and PI values of the blood flow of the ovarian cancer of the patients with positive HE4 and STAT3 were significantly lower than those of the patients with negative HE4 and STAT3(all P<0.05).There was a positive correlation between the HE4 expression and the STAT3 expression in ovarian cancer tissue(P<0.05).Conclusion:The expression levels of HE4 and STAT3 in ovarian cancer tissues of the patients increase and their blood flow parameters(RI and PI)of the blood flow of the ovarian cancer by TVCDS decrease abnormally.The com bination of the expressions of HE4 and STAT3 in ovarian cancer tissues,and blood flow parameters of ovarian cancer by TVCDS of the patients can be

关 键 词：卵巢癌组织 人附睾上皮分泌蛋白4 信号转导和转录激活因子3 经阴道彩色多普勒超声 

分 类 号：R737.31[医药卫生—肿瘤]