ALDH2基因多态性与冠心病患者冠脉病变程度及预后的关系  

Relation between ALDH2 gene polymorphism and the severity of coronary artery disease and the prognosis in patients with coronary heart disease

作　　者：耿旭[1] 张先林[1] 王健[1] 黄宇理[1] 周开恩 高大胜[1] GENG Xu;ZHANG Xianlin;WANG Jian;HUANG Yuli;ZHOU Kaien;GAO Dasheng(Dept.of Cardiology,the 1st Affiliated Hospital of Bengbu Medical College,Bengbu 233000;Bengbu Medical College,Bengbu 233030,China)

机构地区：[1]蚌埠医学院第一附属医院,安徽蚌埠233000 [2]蚌埠医学院,安徽蚌埠233030

出　　处：《华夏医学》2022年第5期13-16,共4页Acta Medicinae Sinica

基　　金：蚌埠医学院自然科学重点项目(BYKY2019080ZD);国家级大学生创新训练计划项目(202010367016)。

摘　　要：目的:探索不同冠脉病变支数组乙醛脱氢酶2(ALDH2)基因型分布特点与CRP、SOD及NLR水平是否有差异,并分析不同基因型对介入治疗预后的影响。方法:选取227例经冠状动脉造影术确诊的冠心病患者,分析不同冠脉病变支数组的ALDH2基因型及CRP、SOD和NLR水平;比较不同ALDH2基因型并接受介入治疗后患者的胸痛再发、心肌梗死等不良事件。结果:不同冠脉病变分支组GG型所占比例有统计学差异(P<0.05);不同ALDH2基因型冠心病患者的CRP、SOD及NLR水平比较,无统计学差异(P>0.05);不同ALDH2基因型患者接受介入治疗后的胸痛再发、心肌梗死等比较,无统计学差异(P>0.05)。结论:ALDH2基因多态性与冠脉病变程度具有相关性,但与CRP、SOD及NLR无相关性,ALDH2基因型与冠心病介入治疗的预后无相关性。Objective: To investigate whether there are differences in the distribution characteristics of aldehyde dehydrogenase 2(ALDH2) genotype and the levels of CRP, SOD and NLR in different coronary artery disease groups, and to analyze the effect of different genotypes on the prognosis of interventional therapy in patients. Methods: 227 patients diagnosed with coronary heart disease(CHD) were to undergo coronary angiography and were selected to analyze the ALDH2 genotypes, CRP, SOD and NLR levels in different groups of coronary artery lesions. Then, the recurrence rate of such adverse events as chest pain and myocardial infarction after interventional therapy were compared among patients with different ALDH2 genotypes. Results: The proportion of GG type was different among different number of coronary artery lesions(P<0.05);there were no significant differences in CRP, SOD and NLR levels among CHD patients with different genotypes(P>0.05);and there was no significant difference in the recurrence rate of chest pain and myocardial infarction among patients with different ALDH2 genotypes after interventional therapy. Conclusion: ALDH2 gene polymorphism is correlated with the degree of coronary artery lesions, but has no significant correlation with CRP, SOD and NLR, and ALDH2 genotype has no significant relation with the prognosis of CHD patients after interventional therapy.

关 键 词：冠心病 ALDH2 基因多态性 冠脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]