IFIT1的抗炎及抗病毒作用概述  

Summary of anti-inflammatory and antiviral effects of IFIT1

作　　者：江伟 陈晓芸[2] 张亚飞 黄成 李俊[1] 王媛媛[2] JIANG Wei;CHEN Xiao-yun;ZHANG Ya-fei;HUANG Cheng;LI jun;WANG Yuan-yuan(School of Pharmacy,Anhui Medical University,Hefei 230032,China;Dept of Pharmacology,the Second Hospital of Anhui Medical University,Hefei 230601,China)

机构地区：[1]安徽医科大学药学院,安徽合肥230032 [2]安徽医科大学第二附属医院药学部,安徽合肥230601

出　　处：《中国药理学通报》2023年第1期5-8,共4页Chinese Pharmacological Bulletin

基　　金：安徽省高校协同创新计划(NoGXXT-2019-045);安徽医科大学校科研基金(No2020xkj190);白求恩肿瘤临床研究计划项目(NoBCF-XD-ZL-20220118-041)。

摘　　要：IFIT1是一种高度诱导的具有四肽重复序列的干扰素刺激基因家族(ISGs)成员,主要存在于细胞质,其表达受干扰素(IFN)、多种病毒和某些病原体相关分子模式的调节,具有抗病毒、抗炎等作用。IFIT1的抗病毒作用可通过多种机制和途径发挥,同时部分病毒也进化出独特的机制逃避宿主IFIT1的限制作用,从而对抗机体抗病毒免疫。在许多炎症性疾病中,IFIT1也显示出其独特的抗炎作用。该文就IFIT1的抗炎和抗病毒作用与相关机制作一综述,为进一步研究相关疾病的治疗提供新的靶点和思路。IFIT1 is a highly inducible member of the interferon stimulating gene family(ISGs)with tetrapeptide repeats.It mainly exists in the cytoplasm and is regulated by interferon,a variety of antiviral role through a variety of mechanisms and pathways,and many viruses have evolved unique mechanisms to evade the limiting effects of IFIT1 and thus counter the body’s antiviral immunity.the unique anti-inflammatory effect of IFIT1 has been extensively studied in inflammatory diseases,Therefore,we mainly review the anti-inflammatory and antiviral effects of IFIT1 and the related mechanisms,so as to provide new therapeutic targets and ideas for the treatment of related diseases.

关 键 词：IFIT1 抗炎 抗病毒 干扰素 作用机制 药物治疗 

分 类 号：R364.5[医药卫生—病理学] R392.11[医药卫生—基础医学] R971.1R977.6R978.7