甲状腺乳头状癌合并桥本甲状腺炎患者的血清甲状腺过氧化物酶抗体、甲状腺球蛋白抗体水平及临床意义  

Serum levels of thyroid peroxidase antibody and thyroglobulin antibody in papillary thyroid carcinoma patients combined with Hashimoto thyroiditis and their clinical significance

作　　者：李欣[1] 邱伟[1] 周浩锋 洪妍妍 LI Xin;QIU Wei;ZHOU Haofeng;HONG Yanyan(Department of Endocrinology,Xinxiang First People’s Hospital,Xinxiang 453000,He’nan,China)

机构地区：[1]新乡市第一人民医院内分泌科,河南新乡4530000

出　　处：《癌症进展》2022年第22期2311-2314,共4页Oncology Progress

摘　　要：目的探讨甲状腺乳头状癌(PTC)合并桥本甲状腺炎(HT)患者的血清甲状腺过氧化物酶抗体(TPO-Ab)、甲状腺球蛋白抗体(TgAb)水平及临床意义。方法选取100例PTC合并HT患者、100例HT患者、100例健康体检者,分别作为A组、B组、C组,比较3组研究对象的血清TPO-Ab、TgAb水平及甲状腺功能指标[游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)]水平,比较3组研究对象的TPO-Ab、TgAb、FT_(3)、FT_(4)、TSH阳性率,比较不同临床特征PTC合并HT患者的TPO-Ab、TgAb、FT_(3)、FT_(4)、TSH阳性率,采用Spearman相关分析法分析TPO-Ab、TgAb与FT_(3)、FT_(4)、TSH的相关性。结果A组患者的血清TPO-Ab、TgAb、TSH水平均高于B组和C组,血清FT_(3)、FT_(4)水平均低于B组和C组,B组患者的血清TPO-Ab、TgAb、TSH水平均高于C组,血清FT_(3)、FT_(4)水平均低于C组,差异均有统计学意义(P<0.05)。A组患者TPO-Ab、TgAb、FT_(3)、FT_(4)、TSH阳性率均高于B组和C组,B组患者TPO-Ab、TgAb、FT_(3)、FT_(4)、TSH阳性率均高于C组,差异均有统计学意义(P<0.05)。不同肿瘤直径PTC合并HT患者的TPO-Ab、TgAb、FT_(3)、FT_(4)、TSH阳性率比较,差异均无统计学意义(P>0.05)。不同分化程度、临床分期、淋巴结转移情况PTC合并HT患者的TPO-Ab、TgAb、FT_(3)、FT_(4)、TSH阳性率比较,差异均有统计学意义(P<0.01)。TPO-Ab、TgAb与FT_(3)、FT_(4)均呈负相关(P<0.05),TPO-Ab、TgAb与TSH均呈正相关(P<0.05)。结论PTC合并HT患者的血清TPO-Ab、TgAb水平均较高,血清TPO-Ab、TgAb水平与甲状腺功能指标存在一定的相关性,临床可通过检测TPO-Ab、TGAb变化,评估PTC合并HT患者的疾病严重程度。Objective To explore the serum levels of thyroid peroxidase antibody(TPO-Ab)and thyroglobulin antibody(TgAb)in papillary thyroid carcinoma(PTC)patients combined with Hashimoto thyroiditis(HT)and their clinical significance.Method A total of 100 PTC patients combined with HT,100 patients with HT and 100 healthy subjects were enrolled into group A,group B and group C respectively.The serum TPO-Ab,TgAb levels,and thyroid function indexes[free triiodothyronine(FT_(3)),free thyroxine(FT_(4)),and thyrotropin(TSH)]of the three groups,the positive rates of TPO-Ab,TgAb,FT_(3),FT_(4) and TSH of the three groups,and the positive rates of TPO-Ab,TgAb,FT_(3),FT_(4),and TSH in PTC combined with HT patients with different clinical characteristics were compared.The correlation of TPO-Ab and TgAb with FT_(3),FT_(4),and TSH were analyzed by Spearman correlation analysis.Result The serum TPO-Ab,TgAb and TSH levels in group A were higher,serum FT_(3) and FT_(4) levels were lower than those in group B and group C;the serum TPO-Ab,TgAb and TSH levels in group B were higher,serum FT_(3) and FT_(4) levels were lower than those in group C(P<0.05).The positive rates of TPO-Ab,TgAb,FT_(3),FT_(4) and TSH in group A were higher than those in group B and group C,and the above indictors in group B were higher than those in group C(P<0.05).There were no significant differences in the positive rates of TPO-Ab,TgAb,FT_(3),FT_(4)and TSH in PTC combined with HT patients with different tumor diameters(P>0.05).There were significant differences for the positive rates of TPO-Ab,TgAb,FT_(3),FT_(4) and TSH in PTC combined with HT patients with different differentiation,clinical stages and lymph node metastasis(P<0.01).TPO-Ab and TgAb were negatively correlated with FT_(3) and FT_(4)(P<0.05),positively correlated with TSH(P<0.05).Conclusion Serum TPO-Ab and TgAb are highly expressed in PTC patients combined with HT,and are correlated with thyroid function indexes.Changes of serum TPO-Ab and TgAb can be detected clinically to assess the severity of the di

关 键 词：甲状腺乳头状癌 桥本甲状腺炎 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 

分 类 号：R736.1[医药卫生—肿瘤]