肿瘤细胞减灭术联合洛铂术中腹腔灌注治疗在老年原发性卵巢癌患者中的应用效果  

Application effect of cytoreductive surgery combined with intraperitoneal perfusion of lobaplatin in the treatment of elderly patients with primary ovarian cancer

作　　者：宗玫 杨影 孙付霞 ZONG Mei;YANG Ying;SUN Fuxia(Department of Gynaecology and Obstetrics,Zhumadian Hospital of Traditional Chinese Medicine,Zhumadian 463000,He’nan,China)

机构地区：[1]驻马店市中医院妇产科,河南驻马店463000

出　　处：《癌症进展》2022年第22期2356-2359,共4页Oncology Progress

摘　　要：目的探讨肿瘤细胞减灭术联合洛铂术中腹腔灌注治疗在老年原发性卵巢癌患者中的应用效果。方法根据治疗方式的不同将166例老年原发性卵巢癌患者分为手术治疗组和联合化疗组,每组83例,手术治疗组患者采用肿瘤细胞减灭术治疗,联合化疗组患者采用肿瘤细胞减灭术联合洛铂术中腹腔灌注治疗。比较两组患者的围手术期指标、T淋巴细胞因子水平、肿瘤标志物[人附睾蛋白4(HE4)、血管内皮生长因子(VEGF)、糖类抗原125(CA125)]水平及不良反应发生率。结果联合化疗组患者的手术时间明显长于手术治疗组,术中出血量、术中腹腔积液量均明显少于手术治疗组,住院时间明显短于手术治疗组,差异均有统计学意义(P<0.01)。治疗后,两组患者的CD3^(+)CD4^(+)、CD3^(+)CD56^(+)、CD3^(+)CD4^(+)/CD3^(+)CD56^(+)均高于本组治疗前,联合化疗组患者的CD3^(+)CD4^(+)、CD3^(+)CD56^(+)、CD3^(+)CD4^(+)/CD3^(+)CD56^(+)均高于手术治疗组,差异均有统计学意义(P<0.05)。治疗后,两组患者的HE4、VEGF、CA125水平均低于本组治疗前,联合化疗组患者的HE4、VEGF、CA125水平均低于手术治疗组,差异均有统计学意义(P<0.05)。两组患者恶心呕吐、心脏毒性、肝脏损伤、神经毒性、骨髓抑制发生率比较,差异均无统计学意义(P>0.05)。结论肿瘤细胞减灭术联合洛铂术中腹腔灌注可有效改善老年原发性卵巢癌患者的围手术期指标,提高机体免疫力,降低肿瘤标志物水平,且安全性较高。Objective To investigate the application effect of cytoreductive surgery combined with intraperitoneal perfusion of lobaplatin in the treatment of elderly patients with primary ovarian cancer.Method A total of 166 elderly patients with primary ovarian cancer were divided into surgery group and combined chemotherapy group according to different treatment methods,with 83 cases in each group.The patients in the surgery group were treated with cytoreductive surgery,and the patients in the combined chemotherapy group were treated with cytoreductive surgery combined with intraperitoneal perfusion of lobaplatin.The perioperative indicators,T lymphocyte factor levels,tumor markers[human epididymis protein 4(HE4),vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125)]levels,and adverse events were compared between the two groups.Result The operation time in the combined chemotherapy group was significantly longer than that in the surgery group,the intraoperative blood loss and intraoperative ascites volume were significantly less than those in the surgery group,and the length of hospital stay was significantly shorter than that in the surgery group,and the differences were statistically significant(P<0.01).After the treatment,the levels of CD3^(+)CD4^(+),CD3^(+)CD56^(+)and CD3^(+)CD4^(+)/CD3^(+)CD56^(+)in the two groups were higher than those before the treatment,the indicators in the combined chemotherapy group were higher than those in the surgery group,and the differences were statistically significant(P<0.05).After the treatment,the levels of HE4,VEGF,and CA125 in the two groups were lower than those before the treatment,and the indicators in the combined chemotherapy group were lower than those in the surgery group,and the differences were statistically significant(P<0.05).There were no significant differences in the incidence of nausea and vomiting,cardiotoxicity,liver injury,neurotoxicity and bone marrow suppression between the two groups(P>0.05).Conclusion Cytoreductive surgery combined with intr

关 键 词：原发性卵巢癌 肿瘤细胞减灭术 腹腔灌注 洛铂 T淋巴细胞 肿瘤标志物 

分 类 号：R737.31[医药卫生—肿瘤]